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7,3',4'-Tri-O-methylluteolin

Catalog No. TN1291 CAS 29080-58-8

Synonyms: 5-Hydroxy-3',4',7-trimethoxyflavone

7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

7,3',4'-Tri-O-methylluteolin Chemical Structure

7,3',4'-Tri-O-methylluteolin, CAS 29080-58-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 278.00
25 mg	In stock	$ 475.00
50 mg	In stock	$ 682.00
100 mg	In stock	$ 948.00
1 mL * 10 mM (in DMSO)	In stock	$ 197.00

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Purity: 98.66%

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Description	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml
In vitro	5-hydroxy-3?2,4?2,7-trimethoxyflavone significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α±, IL-6, and IL-1β, were obviously reduced by 5-Hydroxy-3',4',7-trimethoxyflavone in a concentration-dependent manner. Moreover, 5-Hydroxy-3',4',7-trimethoxyflavone significantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 5-Hydroxy-3',4',7-trimethoxyflavone with inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions[1]
Source	Natural Products > Verbenaceae > Callicarpa

Synonyms	5-Hydroxy-3',4',7-trimethoxyflavone
Molecular Weight	328.32
Formula	C18H16O6
CAS No.	29080-58-8

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (27.41 mM)

References and Literature

1. Protective effect of 5-hydroxy-3²,4²,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation.Med. Chem. Res.,2016,25(9):1754-67.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Anti-Gastroenteritis Natural Product Library Food as Medicine Compound Library Bioactive Compounds Library Max Bioactive Compound Library Immuno-Oncology Compound Library Anti-Aging Compound Library Tibetan medicine Compound Library

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Keywords

7,3',4'-Tri-O-methylluteolin 29080-58-8 Apoptosis Immunology/Inflammation Neuroscience COX TNF Interleukin TNFR 7,3',4'TriOmethylluteolin lipopolysaccharide Tumor Necrosis Factor Receptor Inflammation-related diseases pro-inflammatory cytokines RAW 264.7 macrophage Interleukin Related inhibit TNF Receptor 5-Hydroxy-3',4',7-trimethoxyflavone Cyclooxygenase 7,3',4' Tri O methylluteolin Inhibitor inhibitor

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