vesicle — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8513	Spastazoline		Others
	Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).		Others
T9063	Clathrin-IN-1		HIV Protease
	Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.		HIV Protease
T6822	Hydroxy-Dynasore	Dyngo-4a	Dynamin
	Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.		Dynamin
T0192	Levetiracetam	UCB L059,SIB-S1	DNA Methyltransferase , Others , Calcium Channel
	Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...		DNA Methyltransferase , Others , Calcium Channel
T20789	S-23	(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23	Androgen Receptor
	S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve...		Androgen Receptor
T19711	Desmosterol	Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite
	Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.		Endogenous Metabolite
T74305	14:0 PEG2000 PE	DMPE-PEG2000	Others
	14:0 PEG2000 PE (DMPE-PEG2000) is a polyethylene glycol (PEG)-phospholipid coupling that prevents vesicle aggregation in the preparation of vesicle formulations and can be used to prepare nanostructured lipid carriers.		Others
T7724	Tepoxalin	RWJ-20485,RWJ20485,ORF20485,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase , COX
	Tepoxalin (RWJ 20485) is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, COX-2, and 5-LOX. Tepoxalin is a potent inhibitor of sheep seminal vesicle cyclooxyge...		Lipoxygenase , COX
T6887	MCC950 sodium	CRID3 sodium salt,CP-456773,CP-456773 sodium,MCC950	NOD-like Receptor (NLR) , NOD
	MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2...		NOD-like Receptor (NLR) , NOD
T3534	Tetrabenazine Racemate	Nitoman,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE	Monoamine Transporter
	Tetrabenazine Racemate (Rubigen) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). Tetrabenazine Racemate blocks neurotransmitter uptake into adrenergic storage vesicles and has been ...		Monoamine Transporter
T0719	Tetrabenazine	Xenazine,Ro 1-9569	Others , Dopamine Receptor , Monoamine Transporter
	Tetrabenazine (Ro 1-9569) is a drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high...		Others , Dopamine Receptor , Monoamine Transporter
T14855	Calcein	Fluorexon	Others
	Calcein (Fluorexon) is a fluorescent dye and self-quenching probe that used as an indicator of lipid vesicle leakage, and a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determina...		Others
T26357	Pitstop 2		Apoptosis
	Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec...		Apoptosis
T76251L	Ac-FEID-CMK TFA		Pyroptosis
	Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur...		Pyroptosis
T4969	Guanosine 5'-triphosphate trisodium salt	GTP Trisodium salt,5'-GTP trisodium salt	Endogenous Metabolite
	Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of se...		Endogenous Metabolite
T37020	Endosidin-2	ES2,Endosidin 2
	Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).Endosidin-2 disrupts pro...
T35856	BMS-986176		AAK1 (AP2 associated kinase 1)
	AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...		AAK1 (AP2 associated kinase 1)
T69069	Endosidin1
	Endosidin1 is a natural vesicle trafficking inhibitor.
T39069	UCB-J
	UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].
T38407	RTIL 13
	RTIL 13 is a highly effective inhibitor of dynamin GTPase, exhibiting an IC50 value of 2.3 μM for dynamin I GTPase. Furthermore, it selectively interacts with the pleckstrin homology lipid binding domain. This compound e...