Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Dyngo-4a , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.
Description | Dyngo-4a , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively. |
Targets&IC50 | DynI (brain):0.38 μM, DynII (rec):2.3 μM, DynI (rec):1.1 μM |
In vitro | Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. [3] |
Synonyms | Dyngo-4a |
Molecular Weight | 338.31 |
Formula | C18H14N2O5 |
CAS No. | 1256493-34-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 32.2 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Hydroxy-Dynasore 1256493-34-1 Cytoskeletal Signaling Dynamin inhibit vesicle Hydroxy Dynasore Neuron clathrin‐coated Dyngo-4a Inhibitor Endocytosis,Dynamin,GTPase HydroxyDynasore inhibitor