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Hydroxy-Dynasore
🥰Excellent
Catalog No. T6822Cas No. 1256493-34-1
Alias Dyngo-4a
Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.
Hydroxy-Dynasore
🥰Excellent
Purity: 100%
Catalog No. T6822Alias Dyngo-4aCas No. 1256493-34-1
Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $46 | In Stock | |
| 10 mg | $76 | In Stock | |
| 25 mg | $139 | In Stock | |
| 50 mg | $233 | In Stock | |
| 100 mg | $347 | In Stock | |
| 200 mg | $516 | In Stock | |
| 500 mg | $825 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Dynapyrazole A
T355482226517-75-3
Dynapyrazole A is a specific inhibitor of microtubule dynamin with IC50s of 2.3 and 2.6 μM for dynein 1 and dynein 2-dependent microtubule gliding, and it inhibits Hedgehog signaling with an IC50 of 1.9 μM.
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively. |
| Targets&IC50 | DynII (rec):2.3 μM, DynI (rec):1.1 μM, DynI (brain):0.38 μM |
| In vitro | Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. [3] |
| Alias | Dyngo-4a |
| Molecular Weight | 338.31 |
| Formula | C18H14N2O5 |
| Cas No. | 1256493-34-1 |
| Smiles | Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O |
| Relative Density. | 1.45 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (133.01 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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