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Hydroxy-Dynasore

Catalog No. T6822 CAS 1256493-34-1

Synonyms: Dyngo-4a

Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.

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Hydroxy-Dynasore, CAS 1256493-34-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 46.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 139.00
50 mg	In stock	$ 233.00
100 mg	In stock	$ 347.00
200 mg	In stock	$ 516.00
500 mg	In stock	$ 825.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 98%

Biological Description

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Description	Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.
Targets&IC50	DynI (brain):0.38 μM, DynI (rec):1.1 μM, DynII (rec):2.3 μM
In vitro	Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC?? of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. [1] In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. [2] In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. [3]

Synonyms	Dyngo-4a
Molecular Weight	338.31
Formula	C18H14N2O5
CAS No.	1256493-34-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.2 mg/mL (100 mM)

References and Literature

1. McCluskey A, et al. Traffic. 2013, 14(12), 1272-1289. 2. Harper CB, et al. J Biol Chem. 2011, 286(41), 35966-35976. 3. Gagliardi M, et al. J Cell Sci. 2014, 127(22), 4918-4926. 4. . Dyngo-4a protects mice from rotavirus infection by affecting the formation of dynamin 2 oligomers. Science Bulletin. 2020

Citations

1. Quanzhi Zhang 1,a,b, Qiuhan Zhang 1,b, Zhichao Xu c, Qi Tang b, Xinjin Liu b, Danping Niu b, Xiaoming Gao a, Ke Lan b,*, Shuwen Wu. Dyngo-4a protects mice from rotavirus infection by affecting the formation of dynamin 2 oligomers. Science Bulletin. 2020

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Dynapyrazole A Dynamin inhibitory peptide, myristoylated acetate Trimethyloctadecylammonium bromide Dynasore Schaftoside Tetradecyltrimethylammonium bromide Mdivi-1 Dynamin IN-2

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hydroxy-Dynasore 1256493-34-1 Cytoskeletal Signaling Dynamin inhibit vesicle Hydroxy Dynasore Neuron clathrin‐coated Inhibitor Endocytosis,Dynamin,GTPase Dyngo-4a HydroxyDynasore inhibitor

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