thrombotic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T3P2904	α-Linolenic acid	Alpha-Linolenic Acid,Linolenic acid	Akt , PI3K
	α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostagland...		Akt , PI3K
T25364L	Efegatran sulfate	LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate	Thrombin
	Efegatran sulfate (LY294468 sulfate) is a potent thrombin inhibitor used in the treatment of thrombotic disorders.		Thrombin
T3809	Liriope muscari baily saponins C		Others
	Liriope muscari baily saponins C has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of TF and IL-6.		Others
T68092	Letaxaban	TAK-442	Factor Xa
	Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages.		Factor Xa
T20765	Atorvastatin		HMG-CoA Reductase , Autophagy
	Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i...		HMG-CoA Reductase , Autophagy
T2S1749	Protogracillin		Others
	Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis.		Others
T70106	F-050
	F-050 is a biochemical that has been shown to inhibit platelet aggregation induced by CaCl2, arachidonic acid, collagen, adenosine diphosphate (ADP) and thrombin in guinea pigs, rabbits and rats in vitro. F-050 may be us...
T11659	Inogatran	H-314-27	Others
	Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.		Others
T40802	Poloxamer 188
	Poloxamer 188, a nonionic linear copolymer possessing surfactant properties, demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective activities across different tissue injury models.
T71429	O-Demethyl apixaban sulfate
	O-Demethyl apixaban sulfate is a metabolite of Apixaban, a potent and highly selective factor Xa inhibitor. Apixaban is currently under development for treatment of arterial and venous thrombotic diseases.
TN1312	6-Hydroxykaempferol 3-O-β-D-glucoside	6-Hydroxykaempferol 3-O-beta-D-glucoside	Others
	6-Hydroxykaempferol 3-O-beta-D-glucoside has anti-thrombotic,and antioxidative activities.		Others
T62949	(1R,3S)-THCCA-Asn
	(1R,3S)-THCCA-Asn (4j) is a selective inhibitor of thrombin (IC50: 0.07-0.14 μM) with anti-thrombotic effects.
TN1550	Danshenxinkun A		Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interactio...		Others
TN2106	Protodeltonin		BCL , PARP , Caspase
	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhibit the proliferation of a panel of established human and m...		BCL , PARP , Caspase
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is...
T78666	Egaptivon pegol	ARC 1779	Integrin
	Egaptivon pegol (ARC1779) is an aptamer that inhibits the interaction of von Willebrand Factor (VWF) with platelet GPIb receptors, exhibiting anti-thrombotic efficacy.		Integrin
T75689	Mumefural
	Mumefural, a bioactive compound found in the processed fruit of Prunus mume Sieb., inhibits platelet aggregation, exhibits anti-thrombotic properties, and ameliorates cognitive impairment [1] [2].
T3839	Cycloolivil	Isoolivil	Free radical scavengers , Others , Platelet aggregation
	Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated t...		Free radical scavengers , Others , Platelet aggregation
T64257	FXIa-IN-8
	FXIa-IN-8 is a potent and selective inhibitor of FXIa (IC50: 14.2 nM). FXIa-IN-8 exhibits anti-thrombotic effects and does not increase the risk of bleeding or significant toxicity sup>[1].