stimulation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6878	LJI308		S6 Kinase
	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.		S6 Kinase
T8235	L-732138		Neurokinin receptor
	L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)		Neurokinin receptor
T16074	Mifobate	SR-202	PPAR
	Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].		PPAR
T2198	Arecoline hydrobromide	Arecoline HBr,Arecoline bromide	AChR
	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.		AChR
T0096	Vardenafil	Vivanza,Levitra,Vardenafil hydrochloride	PDE
	Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...		PDE
T8405	Vardenafil hydrochloride		PDE
	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes		PDE
T4097	Vardenafil hydrochloride trihydrate	Vardenafil HCl Trihydrate,BAY38-9456	PDE
	Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
T4480	Vardenafil dihydrochloride	Levitra,Vardenafil Hydrochloride	PDE
	Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
TQ0273	Neopterin	D-(+)-Neopterin,2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one	Endogenous Metabolite
	D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ. In humans, neopterin is involved in purine biosynthesis.		Endogenous Metabolite
T5641	RP-54745		Interleukin
	RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.		Interleukin
TP2365L	Acetyl tetrapeptide-9 Acetate	Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base)	Others
	Acetyl tetrapeptide-9 Acetate plays a role in the stimulation of basement membrane polysaccharide (lumican) and the synthesis of collagen I.		Others
T9544	Compound 1T-0216		Others
	Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation.		Others
T4068	E6446 dihydrochloride		TLR
	E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.		TLR
T23536	Xamoterol hemifumarate	ICI 118587 hemifumarate,Corwin hemifumarate	Adrenergic Receptor
	Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr...		Adrenergic Receptor
T9545	Compound 1T-0219 (SC)		FAK
	Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylati...		FAK
T29087	VA-K-14 hydrochloride	VAK14 Hydrochloride,VA K 14 HCl,VA-K-14 HCl,VAK14 HCl	TSH Receptor
	VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogate...		TSH Receptor
T5327	Amezinium methylsulfate	Amezinium metilsulfate,Amezinium (methylsulfate),Lu-1631	Adrenergic Receptor
	Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.		Adrenergic Receptor
T6S0627	Mesaconitine		TNF
	1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system.		TNF
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
TP1896L1	Kisspeptin 234 acetate(1145998-81-7 free base)		GPR , Kisspeptin
	Kisspeptin 234 acetate is a kisspeptin receptor antagonist. Kisspeptin 234 inhibits kisspeptin-10 stimulation of IP (IC50 = 7 nM) and release of GnRH.		GPR , Kisspeptin