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Amezinium methylsulfate

Catalog No. T5327 CAS 30578-37-1

Synonyms: Amezinium metilsulfate, Amezinium (methylsulfate), Lu-1631

Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.

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Amezinium methylsulfate Chemical Structure

Amezinium methylsulfate, CAS 30578-37-1

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 48.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.74%

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Description

Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake.

In vivo

In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %) [1]. The reduction ratio of FTBF was significantly increased by amezimium [placebo, 75.9%; amezinium, 85.1%; midodrine, 78.1%]. The infusion rate of noradrenaline producing a half-maximum venoconstriction was significantly decreased by amezinium (placebo, 40.6 ng/min; amezinium, 21.0 ng/min) [2].

Synonyms	Amezinium metilsulfate, Amezinium (methylsulfate), Lu-1631
Molecular Weight	313.33
Formula	C12H15N3O5S
CAS No.	30578-37-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (159.58 mM)

References and Literature

1. Sakakibara R, et al. Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin Auton Res. 2003 Feb;13(1):51-3. 2. Harada K, et al. Effect of amezinium metilsulfate on the finger skin vasoconstrictor response to cold stimulation and venoconstrictor response to noradrenaline. Jpn Circ J. 1998 Nov;62(11):824-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library GPCR Compound Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Approved Drug Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

Amezinium methylsulfate 30578-37-1 GPCR/G Protein Neuroscience Adrenergic Receptor Amezinium metilsulfate Lu 1631 inhibit Lu1631 methylsulfate Beta Receptor Amezinium (methylsulfate) Inhibitor Amezinium Lu-1631 inhibitor

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