Powder: -20°C for 3 years
In solvent: -80°C for 2 years
RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and <a href="/target/Interleukin" style="display: inline; color: #c13a36">Interleukin</a>-1 production.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
2 mg | In stock | $ 166.00 | |
5 mg | In stock | $ 221.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 654.00 | |
50 mg | In stock | $ 977.00 | |
100 mg | In stock | $ 1,471.00 | |
200 mg | In stock | $ 2,199.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 359.00 |
Description | RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production. |
In vivo | RP-54745 might diminishe?LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1],RP-54745 might influence cells and cytokines implicated in the regulation of the immune system, the disfunctioning of which can lead to inflammatory disorders or autoimmune pathologies[2] |
Animal Research | 1.5*10^6 peritoneal murine macrophages, after a 2-h period of adherence, were cultured in RPMI 1640 with 5% FCS for 20 h at 37 ℃ in 5% CO2.?In vitro, test compounds were added 15 min before the stimulant, 100ng/ml LPS, and the cells were incubated for 2-24 h. In vivo, thioglycollate-stimulated female OFt mice were orally treated with 5 or 25 mg/kg/day RP 54745 for 4 days.?Harvested macrophages were then stimulated ex vivo for 2 h with LPS at concentrations ranging from 0.1-10 ng/ml.?In some assays, 4 h before macrophage harvesting, mice were treated intraperitoneally with LPS: 0.5 ug per mouse.?At the end of the in vitro incubation period, supernatants were removed from cultures, and cells were lysed by three freeze/thaw cycles.?Both extracellular and cell-associated IL-1 activities were assayed. |
Molecular Weight | 297.82 |
Formula | C13H12ClNOS2 |
CAS No. | 135330-08-4 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 62.5 mg/mL (209.86 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RP-54745 135330-08-4 Immunology/Inflammation Interleukin inhibit RP 54745 Inhibitor RP54745 Interleukin Related inhibitor