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RP-54745

Catalog No. T5641 CAS 135330-08-4

RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and <a href="/target/Interleukin" style="display: inline; color: #c13a36">Interleukin</a>-1 production.

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RP-54745, CAS 135330-08-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 113.00
2 mg	In stock	$ 166.00
5 mg	In stock	$ 221.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 654.00
50 mg	In stock	$ 977.00
100 mg	In stock	$ 1,471.00
200 mg	In stock	$ 2,199.00
1 mL * 10 mM (in DMSO)	In stock	$ 359.00

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Purity: 98%

Biological Description

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Description	RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
In vivo	RP-54745 might diminishe?LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1],RP-54745 might influence cells and cytokines implicated in the regulation of the immune system, the disfunctioning of which can lead to inflammatory disorders or autoimmune pathologies[2]
Animal Research	1.5*10^6 peritoneal murine macrophages, after a 2-h period of adherence, were cultured in RPMI 1640 with 5% FCS for 20 h at 37 ℃ in 5% CO2.?In vitro, test compounds were added 15 min before the stimulant, 100ng/ml LPS, and the cells were incubated for 2-24 h. In vivo, thioglycollate-stimulated female OFt mice were orally treated with 5 or 25 mg/kg/day RP 54745 for 4 days.?Harvested macrophages were then stimulated ex vivo for 2 h with LPS at concentrations ranging from 0.1-10 ng/ml.?In some assays, 4 h before macrophage harvesting, mice were treated intraperitoneally with LPS: 0.5 ug per mouse.?At the end of the in vitro incubation period, supernatants were removed from cultures, and cells were lysed by three freeze/thaw cycles.?Both extracellular and cell-associated IL-1 activities were assayed.

Molecular Weight	297.82
Formula	C13H12ClNOS2
CAS No.	135330-08-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 62.5 mg/mL (209.86 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Folliard F , Bousseau A , Terlain B . RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production[J]. Agents and Actions, 1992, 36(1-2):119-126. 2. Folliard F , Bousseau A , Terlain B . RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models[J]. Agents and Actions, 1992, 36(1-2):127-135.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RP-54745 135330-08-4 Immunology/Inflammation Interleukin inhibit RP 54745 Inhibitor RP54745 Interleukin Related inhibitor

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