sensitization — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21955	GQ-16		PPAR
	GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.		PPAR
T21935L	AMN082 free base	AMN082	GluR
	AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.		GluR
T21935	AMN082	AMN 082 dihydrochloride	GluR
	AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.		GluR
TP2111L	TAT-GluA2 3Y acetate(1404188-93-7 free base)		GluR
	TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis.Systemic administration of Tat-GluA2(3Y) during the induction phase of d-amphetamine blocked maintenance of behavioural sensitization and attenuated the m...		GluR
T14384	AZD8797	KAN-0440567,KAND567	CXCR
	AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventi...		CXCR
T11209	EOAI3402143		DUB
	EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.		DUB
T72947	JBSNF-000028	JBSNF-000028 free base	Others
	JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50s of 0.033 μM, 0.19 μM, a...		Others
T6970	RK33	RK-33,RK 33	COX
	RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.		COX
T65086	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride		Apoptosis , Phosphatase
	Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM) and SK-Hep1 (IC50= 151 μM) cells and inhibits protein pho...		Apoptosis , Phosphatase
T83212	AC-099 hydrochloride		Neuropeptide Y Receptor
	AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced noc...		Neuropeptide Y Receptor
T4431	Olodanrigan	PD-126055,EMA401	RAAS
	Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA...		RAAS
T68398	MI-223
	MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
T28268	ORM-3819
	ORM-3819 is a potent and selective PDE III inhibitor. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization.
T37963	Methylchloroisothiazolinone/Methylisothiazolinone Mixture
	Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002,...
T69976	WS-691
	WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the...
T68870	SU-11752
	SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in ...
T35675	SW203668 (trifluoroacetate salt)
	SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other...
TN4585	Moronic acid		HIV Protease , Antifection , HSV
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. ...		HIV Protease , Antifection , HSV
T71223	SR-33805
	SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting ...
T68663	GPI-15427
	GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiform...