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AMN082

Catalog No. T21935 CAS 97075-46-2

Synonyms: AMN 082 dihydrochloride

AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.

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AMN082, CAS 97075-46-2

Pack Size	Availability	Price/USD
2 mg	5 days	$ 92.00
5 mg	5 days	$ 138.00
10 mg	5 days	$ 198.00
25 mg	5 days	$ 356.00
50 mg	5 days	$ 513.00
100 mg	5 days	$ 798.00
200 mg	5 days	$ 1,197.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity.
In vitro	AMN082 inhibited 4-aminopyridine-evoked glutamate release and this phenomenon was blocked by the metabotropic glutamate mGlu7 receptor antagonist MMPIP.?Moreover, western blot analysis and immunocytochemistry confirmed the presence of presynaptic metabotropic glutamate mGlu7 receptor proteins.?The effect of AMN082 on the 4-aminopyridine-evoked release of glutamate was prevented by chelating the extracellular Ca2+ ions and the vesicular transporter inhibitor.[1]
In vivo	Pretreatment of animals with the lower doses of AMN082 (1.25 5.0 mg/kg, i.p.), 30 min before every cocaine or morphine injection during repeated drug administration or before cocaine or morphine challenge, dose-dependently attenuated the development, as well as the expression of cocaine or morphine locomotor sensitization.[2]

Synonyms	AMN 082 dihydrochloride
Molecular Weight	465.46
Formula	C28H30Cl2N2
CAS No.	97075-46-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wang CC, et al. Metabotropic glutamate 7 receptor agonist AMN082 inhibits glutamate release in rat cerebral cortex nerve terminal. Eur J Pharmacol. 2018;823:11-18. 2. Jenda M, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;57:166-175.

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Keywords

AMN082 97075-46-2 Neuroscience GluR inhibit Inhibitor AMN 082 dihydrochloride allosteric mGluR AMN 082 Dihydrochloride hormone oral Metabotropic glutamate receptors stress sensitization AMN-082 AMN082 Dihydrochloride AMN 082 locomotor blood-brain AMN-082 Dihydrochloride barrier inhibitor

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