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EOAI3402143

Catalog No. T11209   CAS 1699750-95-2

EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.

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EOAI3402143 Chemical Structure
EOAI3402143, CAS 1699750-95-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
5 mg In stock $ 83.00
10 mg In stock $ 137.00
25 mg In stock $ 247.00
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Purity: 98.09%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.
In vitro EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[2]. Usp9x inhibition by EOAI3402143 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels[2].
In vivo EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[3].
Molecular Weight 503.42
Formula C25H28Cl2N4O3
CAS No. 1699750-95-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/mL (148.98 mM), sonification is recommended.

H2O: < 0.1 mg/mL (insoluble)

TargetMolReferences and Literature

1. Potu H, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014 Jul 30;5(14):5559-69. 2. Pal A, et al. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 Feb;20(2):152-164. 3. Peterson LF, et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125(23):3588-97.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Covalent Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Ubiquitination Compound Library Anti-Cancer Compound Library HIF-1 Signaling Pathway Compound Library Inhibitor Library

Related Products

Related compounds with same targets
IU1-248 USP7-IN-6 P 22077 USP30 inhibitor 11 USP8-IN-3 IMP-1710 FT827 Degrasyn

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Keywords

EOAI3402143 1699750-95-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB Inhibitor Deubiquitinase DUBs inhibit EOAI-3402143 EOAI 3402143 inhibitor

 

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