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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T81283 | RGD-targeted Proapoptotic Peptide | ||
RGD-Targeted Proapoptotic Peptide is a peptide that preferentially binds to integrins at sites of tumor angiogenesis through its C-terminal RGD-4C sequence (ACDCRGDCFC). | |||
T6641 | Rilmenidine Phosphate | Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor | |
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension. | |||
TP2207 | Pasireotide Acetate | Somatostatin | |
Pasireotide Acetate is a stable cyclohexapeptide somatostatin mimic | |||
T12257 | NSC 146109 hydrochloride | Apoptosis , Others | |
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer. | |||
T19676 | Tributyrin | NSC661583,NSC 661583,NSC-661583 | Apoptosis |
Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracell... | |||
T6079 | NVP-ADW742 | ADW742,ADW,GSK 552602A | Apoptosis , IGF-1R |
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. | |||
TP2306 | Adipotide/FTPP(FatTargetedProapoptoticPeptide) Acetate | Others | |
Adipotide as a prototype in a new class of candidate drugs that may be useful for treating obesity in humans | |||
T2111 | Sepantronium bromide | YM155 | Survivin , Autophagy |
Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity. | |||
T2453 | BAM7 | BCL | |
BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM). | |||
T13818 | Phytohemagglutinin | PHA-M | Apoptosis |
Phytohemagglutinin (PHA-M) is a lectin, isolated from the red kidney bean , induces apoptosis via increasing proapoptotic protein Bax and activating caspases-3. Anti-tumor activity | |||
T13867 | RH01386 | Others | |
RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ... | |||
T4400 | DIM-C-pPhOH | CDIM8 | Apoptosis , Others |
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... | |||
T6301 | Tosedostat | CHR-2797 | Aminopeptidase , AChR |
Tosedostat (CHR-2797) is an orally bioavailable inhibitor of the M1 family of aminopeptidases with potential antineoplastic activity. Tosedostat is converted intracellularly into a poorly membrane-permeable active metabo... | |||
T12369 | Pasireotide pamoate | SOM230 pamoate | Others |
Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity. | |||
T15723 | LBW242 | Others | |
LBW242 is a 3-mer and Smac mimetic and is an effective and orally active proapoptotic IAP inhibitor. LBW242 has activity against multiple myeloma and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian ... | |||
T40643 | Prodigiosin hydrochloride | Prodigiosine hydrochloride | |
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this ... | |||
T72658 | CRIPGBM chloride | ||
cRIPGBM chloride is an orally active, proapoptotic compound derived from glioblastoma multiforme (GBM) cancer stem cells (CSCs). It specifically targets receptor-interacting protein kinase 2 (RIPK2) to trigger caspase 1-... | |||
T26709 | Azadirone | ||
Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, do... | |||
T70430 | XK469 | ||
XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases,... | |||
T19250 | CRIPGBM | TNF | |
cRIPGBM, a proapoptotic derivative of RIPGBM, selectively induces apoptosis in GBM cancer stem cells (CSCs) by targeting receptor-interacting protein kinase 2 (RIPK2), demonstrating an EC50 of 68 nM in GBM-1 cells [1]. |