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Pasireotide Acetate

Name: Pasireotide Acetate
Brand: TargetMol
SKU: TP2207
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP2207Cas No. 396091-76-2

Pasireotide (SOM230) acetate is a long-acting cyclohexapeptide growth hormone inhibitory hormone analog with antisecretory, antiproliferative, and proapoptotic activities.Pasireotide (SOM230) acetate inhibits the secretion of GH, IGF-I, and ACTH, and can be used in the study of acromegaly and Cushing's disease. Pasireotide (SOM230) acetate also enhances the agonist activity of growth inhibitory receptors, with pKi of 8.2, 9.0, 9.1, <7.0 and 9.9 for sst1, 2, 3, 4 and 5, respectively.

Pasireotide Acetate

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Purity: 99.92%

Catalog No. TP2207Cas No. 396091-76-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
2 mg	$148	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$455	In Stock	In Stock
25 mg	$828	In Stock	In Stock
50 mg	$1,320	In Stock	In Stock
100 mg	$1,870	-	In Stock
200 mg	$2,520	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

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COA MS HPLC

Product Introduction

Bioactivity

Description	Pasireotide (SOM230) acetate is a long-acting cyclohexapeptide growth hormone inhibitory hormone analog with antisecretory, antiproliferative, and proapoptotic activities.Pasireotide (SOM230) acetate inhibits the secretion of GH, IGF-I, and ACTH, and can be used in the study of acromegaly and Cushing's disease. Pasireotide (SOM230) acetate also enhances the agonist activity of growth inhibitory receptors, with pKi of 8.2, 9.0, 9.1, <7.0 and 9.9 for sst1, 2, 3, 4 and 5, respectively.
In vitro	Pasireotide (SOM230) acetate enhances agonist activity at growth inhibitory receptors with pKi of 8.2, 9.0, 9.1, less than 7.0 and 9.9 for sst1, 2, 3, 4 and 5, respectively.
In vivo	METHODS: Pasireotide (SOM230) acetate (160 mg/kg, subcutaneous injection, four months) was administered to a MEN1 transgenic mouse model, and the effects of Pasireotide (SOM230) acetate on insulin secretion, glucose levels, tumor growth and survival were tested. RESULTS Pasireotide (SOM230) acetate significantly decreased serum insulin, increased serum glucose, decreased tumor size and increased Pdx1-Cre cell apoptosis. [1]

Chemical Properties

Molecular Weight	1107.26
Formula	C₆₀H₇₀N₁₀O₁₁
Cas No.	396091-76-2
Smiles	CC(O)=O.NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1
Relative Density.	no data available
Sequence Short	Cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-{D-Trp}-K-{Tyr(4-Bzl)}-F]

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (45.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9031 mL	4.5157 mL	9.0313 mL	45.1565 mL
5 mM	0.1806 mL	0.9031 mL	1.8063 mL	9.0313 mL
10 mM	0.0903 mL	0.4516 mL	0.9031 mL	4.5157 mL
20 mM	0.0452 mL	0.2258 mL	0.4516 mL	2.2578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc