postsynaptic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5766	(+)-Coclaurine	Coclaurine	Others
	(+)-Coclaurine is a natural product.		Others
T3478	Ro 67-7476		GluR
	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.		GluR
TQ0084	Lumateperone Tosylate	ITI-007	Dopamine Receptor , 5-HT Receptor
	lumateperone Tosylate (ITI-007) is a 5-HT2A receptor antagonist (Ki: 0.54 nM), a SERT blocker (Ki: 61 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki: 32 nM).		Dopamine Receptor , 5-HT Receptor
T21069	Lumateperone	ITI 722,ITI722,ITI-007,ITI007	5-HT Receptor
	Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).		5-HT Receptor
T3377	L-Phenylalanine	(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel , Endogenous Metabolite , iGluR
	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.		Calcium Channel , Endogenous Metabolite , iGluR
T3275	Nefazodone hydrochloride	Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754	5-HT Receptor , Adrenergic Receptor
	Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.		5-HT Receptor , Adrenergic Receptor
T23007	MM 77 dihydrochloride	FITC-Dextran (60842-46-8 MW 4000)	5-HT Receptor
	MM 77 dihydrochloride is an effecitve 5-HT1A receptor postsynaptic antagonist with anxiolytic-like activity.		5-HT Receptor
T0101	Doxazosin mesylate	UK 33274 mesylate	Mitophagy , Adrenergic Receptor , Autophagy
	Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.		Mitophagy , Adrenergic Receptor , Autophagy
T8631	Pyridostigmine	Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum	Others
	Pyridostigmine(Regonol) is an acetylcholinesterase inhibitor that can treat myasthenia gravis by increasing acetylcholine at the postsynaptic motor endplate.		Others
T25672	Lesopitron		5-HT Receptor
	Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withd...		5-HT Receptor
T8452	Dantrolene		Others
	Dantrolene is a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.		Others
T7218	Endomorphin 2		Opioid Receptor
	Endomorphins-2 (EM-2) could decrease both the frequency and amplitude of the sEPSC of the motoneurons in lamina IX, which was reversed by the MOR antagonist CTOP. EM-2-IR fibers originated from primary afferent fibers f...		Opioid Receptor
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
T4440	Saclofen		GABA Receptor
	Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function...		GABA Receptor
T1158	Phenoxybenzamine hydrochloride	NCI-c01661,NSC 37448,Phenoxybenzamine HCl	CaMK , Adrenergic Receptor
	Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non...		CaMK , Adrenergic Receptor
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T13112L1	Tat-NR2B9c acetate	Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate	Others
	Tat-NR2B9c acetate (NA-1 acetate) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c acetate disrupts the PSD-...		Others
TP1945L1	Pep2m, myristoylated acetate	Pep2m, myristoylated acetate(1423381-07-0 free base)	PKC
	Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei...		PKC
T4S0145	Corylifol A	Corylinin	hCE , STAT , UGT
	1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia...		hCE , STAT , UGT
T24462	Mezilamine
	Mezilamine is an antagonist of dopamine. It also blocks presynaptic but stimulating postsynaptic alpha-adrenoceptors.