period — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22891	KL001	KL 001,KL-001	Others
	KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced glu...		Others
T13485	2-Phenylglycine	DL-α-Phenylglycine	Endogenous Metabolite
	2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the lactation period.		Endogenous Metabolite
T19538	(R)-(-)-1,3-Butanediol		Endogenous Metabolite
	(R)-(-)-1,3-Butanediol is a novel ketogenic ester that rapidly increases circulating concentrations of r- and s-ß-hydroxybutyric acid in healthy adults in a short period of time and can be used to study metabolic system-...		Endogenous Metabolite
T9608	KL201		Others
	KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].		Others
T0518	Methacycline hydrochloride	Rondomycin,Methacycline HCl	ribosome , Antibacterial , Antibiotic
	Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.		ribosome , Antibacterial , Antibiotic
T0905	Pyrithioxin	Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen	Others , Endogenous Metabolite
	Pyrithioxin (Encefabol) is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia. Pyrithioxin is regarded as an encephalotropic or nootrop...		Others , Endogenous Metabolite
T6476	Dofetilide	UK 68789,UK-68798,Tikosyn	Potassium Channel
	Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik...		Potassium Channel
T9356	(E/Z)-GO289		Casein Kinase
	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function...		Casein Kinase
T5294	(S)-Leucic acid	L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-(−)-2-Hydroxyisocaproic acid	Others , Endogenous Metabolite
	(S)-Leucic acid (Hydroxyisocaproic acid) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. It belongs to 2-hydroxycarboxylic acid group of amino acid metabolites. (S)-Leucic a...		Others , Endogenous Metabolite
T60777	EM127		ERK , Histone Methyltransferase
	EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methylt...		ERK , Histone Methyltransferase
T4947	3-Hydroxybutyric acid	Butanoic acid	Endogenous Metabolite
	3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, ...		Endogenous Metabolite
T0866	Propafenone	Rythmol,Propafenonum	Potassium Channel , MRP , Sodium Channel
	Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....		Potassium Channel , MRP , Sodium Channel
T4881	Phosphorylethanolamine	O-Phosphorylethanolamine	Others , Endogenous Metabolite
	Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. ...		Others , Endogenous Metabolite
T37821	AP 14145 hydrochloride
	KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rat...
T80849	VU661
	VU661, a redox-active phenazine carboxamide, modulates circadian rhythms by inducing period lengthening.
T29000	Tralomethrin	EPA Pesticide Chemical Code 121501,SAGA,HAG-107,HAG 107,Scout
	Tralomethrin is used as a pyrethroid insecticide. It modifies the gating kinetics of the sodium channels in neurons, increases the length of time the channel remains open after a stimulus, thereby depolarizing the neuron...
T37773	Tetranor-PGEM	tetranor-Prostaglandin E Metabolite,tetranor-PGEM
	tetranor-PGEM is the major urinary metabolite of PGE1 and PGE2, and is used as a marker of PGE2 biosynthesis.[1],[2] About 15% of an infused dose of PGE2 appears as this metabolite in the urine of humans. Normal healthy ...
T36916	Estrone-3-Glucuronide (sodium salt hydrate)
	Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of ferti...
T68502	Dibrospidium Free Base
	Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correl...
T29074	UR-3216
	UR-3216, a prodrug, is a selective and orally active platelet surface glycoprotein (GPIIb/IIIa) receptor antagonist. UR-3216 is the very tight binding of its active metabolite to platelets (Ki for resting platelets is < ...