Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. |
In vitro | KL201 induces a dose-dependent extension of the circadian cycle in both Bmal1-dLuc and Per2-dLuc reporter cells, with a more pronounced reduction in the luminosity of the Per2-dLuc reporter compared to Bmal1-dLuc, without compromising cell viability[1]. It interacts with CRY1, coinciding with the FBXL3 segment of the ubiquitin ligase complex, and its circadian-modulating effects are diminished by the silencing of FBXL3[1]. Moreover, KL201 extends the circadian rhythm and diminishes the brightness of the Per2::Luc reporter in mouse lung primary explants[1]. |
Molecular Weight | 388.28 |
Formula | C17H14BrN3OS |
CAS No. | 302939-48-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (643.87 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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KL201 302939-48-6 Others CRY1 Inhibitor Per2-dLuc FBXL3 inhibit clock circadian cryptochrome KL-201 KL 201 inhibitor