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Phosphorylethanolamine

Catalog No. T4881 CAS 1071-23-4

Synonyms: O-Phosphorylethanolamine

Phosphorylethanolamine (O-Phosphorylethanolamine) is a phosphomonoester metabolite of the phospholipid metabolism. Phosphorylethanolamine is a precursor of phospholipid synthesis and a product of phospholipid breakdown. Phosphomonoesters are present at much higher levels in the brain than in other organs. In developing the brain, phosphomonoesters are normally elevated during the period of neuritic proliferation. This also coincides with the occurrence of normal programmed cell death and synaptic pruning in developing the brain. These findings are consistent with the role of phosphomonoesters in membrane biosynthesis. Phosphorylethanolamine shows a strong structural similarity to the inhibitory neurotransmitter, GABA, and the GABAB receptor partial agonist, 3-amino-propylphosphonic acid. Phosphorylethanolamine is a phosphomonoester which is decreased in post-mortem Alzheimer's disease (AD) brain.

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Phosphorylethanolamine Chemical Structure

Phosphorylethanolamine, CAS 1071-23-4

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Biological Description

Chemical Properties

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Description

Synonyms	O-Phosphorylethanolamine
Molecular Weight	141.06
Formula	C2H8NO4P
CAS No.	1071-23-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

References and Literature

1. Klunk W E, et al. Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites[J]. Life Sciences, 1995, 56(26):2377. 2. Klunk W E, et al. Structural determinants of activity at the GABAB receptor. A comparison of phosphoethanolamine and related GABA analogs.[J]. Mol Chem Neuropathol, 1995, 26(1):15-30. 3. Li G, et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum[J]. Development, 2001, 128(18):3473-3483.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Tobacco Monomer Library Human Endogenous Metabolite Library Traditional Chinese Medicine Monomer Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Alzheimer's Disease Compound Library Human Endogenous Metabolite Compound Library Plus NO PAINS Compound Library

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Keywords

Phosphorylethanolamine 1071-23-4 Metabolism Others Endogenous Metabolite O-Phosphorylethanolamine inhibit NSC254167 Inhibitor NSC 254167 Monoaminoethyl O-Phosphoethanolamine NSC-254167 inhibitor

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