Shopping Cart

Your shopping cart is currently empty

Pyrithioxin (Synonyms: Vitamin B6 disulfide, Pyritinol, Pyridoxine disulfide, Encefabol, Bonifen)

Name: Pyrithioxin
Brand: TargetMol
SKU: T0905
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0905 Copy Product Info

Purity: 98.40%

😃Good

Pyrithioxin (Encefabol) is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia. Pyrithioxin is regarded as an encephalotropic or nootropic compound and is reported to act mainly by producing decisive improvements in cerebral metabolism.

Pyrithioxin

Copy Product Info

😃Good

Catalog No. T0905

Synonyms Vitamin B6 disulfide, Pyritinol, Pyridoxine disulfide, Encefabol, Bonifen

Cas No. 1098-97-1

Pack Size	Price	USA Stock	Global Stock
25 mg	$35	In Stock	In Stock
100 mg	$50	In Stock	In Stock
200 mg	$90	In Stock	In Stock
500 mg	$142	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:98.40%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Pyrithioxin AI Summary

Pyrithioxin possesses multifaceted bioactivities, including inhibiting the vitamin D receptor (VDR) with a potency of 89125.1 nM and Glutaminase (GLS) with a potency of 28183.8 nM. It demonstrates notable antiviral activity against SARS-CoV-2, displaying a hit score of 0.2567 in high-content imaging assays on HRCE cells at 10 µM for 48 hours and showing inhibition of SARS-CoV-2-induced cytotoxicity in Caco-2 cells (-4.36%) and VERO-6 cells (0.1%). The compound inhibits the SARS-CoV-2 3CL-Pro protease by 10.1% at 20 µM concentration. However, its IC50 value for SARS-CoV-2 inhibition in VERO-6 cells exceeds 20000 nM, indicating relatively low potency. Regarding safety, Pyrithioxin exhibits moderate to acute liver toxicity, including elevated ALT or AST serum activity, cytolytic and choleostatic liver toxicity, severe hepatitis, and steatosis, but no chronic liver disease, cirrhosis, granulomatous liver disease, liver damage due to vascular disease, or tumors were reported. Additionally, it shows inhibitory activity against human HDAC6 enzyme, providing 8.3% inhibition with a commercial peptide substrate and 10.06% with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pyrithioxin (Encefabol) is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia. Pyrithioxin is regarded as an encephalotropic or nootropic compound and is reported to act mainly by producing decisive improvements in cerebral metabolism.
Synonyms	Vitamin B6 disulfide, Pyritinol, Pyridoxine disulfide, Encefabol, Bonifen

Chemical Properties

Molecular Weight	368.47
Formula	C₁₆H₂₀N₂O₄S₂
Cas No.	1098-97-1
Smiles	Cc1ncc(CSSCc2cnc(C)c(O)c2CO)c(CO)c1O
Relative Density.	1.448 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (54.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7139 mL	13.5696 mL	27.1393 mL	135.6963 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL	27.1393 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL	13.5696 mL
20 mM	0.1357 mL	0.6785 mL	1.3570 mL	6.7848 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7139 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc