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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11696 | Ivachtin | Caspase-3 Inhibitor VII | Caspase |
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. | |||
T11857 | LIT-001 | Oxytocin Receptor | |
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM. | |||
T16850 | SB-265610 | GSK-CXCR2 | CXCR |
SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and... | |||
T6288 | Mozavaptan | OPC31260l,OPC-31260 | Vasopressin Receptor |
Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 μM and 14 nM, respectively. | |||
T12870 | SCH79797 dihydrochloride | Apoptosis , Others , Protease-activated Receptor | |
SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects. | |||
T3178 | BIBS 39 | RAAS | |
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. | |||
T21790 | BMS 182874 hydrochloride | Endothelin Receptor | |
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. | |||
T27762 | L-162,313 | L-162313,L 162,313,L162,313 | RAAS |
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. | |||
T1520 | Aliskiren hemifumarate | CGP 60536,SPP 100,CGP60536B | RAAS , Autophagy |
Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity. | |||
T3347 | PF3274167 | PF 3274167,Cligosiban,PF-3274167 | OX Receptor |
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. | |||
T39229 | YNT-185 | OX Receptor | |
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of ... | |||
T6281 | TW-37 | TW 37 | BCL |
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM). | |||
T26594 | Allisartan Isoproxil | RAAS | |
Allisartan Isoproxil is a nonpeptide antagonist of angiotensin II receptor and can be used in studies about hypertension and heart diseases. | |||
T25615 | Lanepitant | LY303870,LY-303870,LY 303870 | Others |
Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine. | |||
T9692 | Paltusotine | Somatostatin | |
Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients | |||
TQ0057 | AVE 0991 | Others | |
AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi... | |||
T11174 | (R)-Elagolix | NBI-56418 | GNRH Receptor |
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do... | |||
T8691 | PD 168368 | PD168368 | Bombesin Receptor |
PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist o... | |||
T6825 | Eltrombopag Olamine | Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR | Thrombin |
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom... | |||
T2531L | Eprosartan | KF-108566J free base,Teveten | RAAS |
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... |