Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 287.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 672.00 | |
100 mg | In stock | $ 956.00 | |
500 mg | In stock | $ 1,920.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 223.00 |
Description | LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM. |
Targets&IC50 | OT-R:55 nM (EC50), OT-R:226 nM (Ki) |
In vitro | In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration. |
In vivo | LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1]. |
Molecular Weight | 645.7 |
Formula | C30H34F3N7O4S |
CAS No. | 2245072-21-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 247 mg/mL (382.53mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LIT-001 2245072-21-1 Endocrinology/Hormones GPCR/G Protein Oxytocin Receptor autism Inhibitor interaction inhibit LIT001 OXTR V1a vasopressin nonpeptide social nonbiased receptor disorders spectrum LIT 001 inhibitor