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Endocrinology/Hormones Oxytocin Receptor LIT-001

LIT-001

Catalog No. T11857   CAS 2245072-21-1

LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.

LIT-001, CAS 2245072-21-1
Pack Size Availability Price/USD Quantity
1 mg In stock 94.00
5 mg In stock 193.00
10 mg In stock 358.00
25 mg In stock 565.00
50 mg In stock 979.00
100 mg In stock 1496.00
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500 mg In stock Inquiry
1 mL * 10 mM (in DMSO) In stock 369.00
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Purity 98.25%
Biological Description
Chemical Properties
Storage & Solubility Information
Description LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
Targets&IC50 OT-R
In vitro In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.
In vivo LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1].
Molecular Weight 645.7
Formula C30H34F3N7O4S
CAS No. 2245072-21-1

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 247 mg/mL (382.53mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Neuronal Signaling Compound Library Endocrinology-Hormones Library GPCR Compound Library

Related Products

Related compounds with same targets
LIT-001 Oxytocin acetate (50-56-6 free base) Atosiban acetate (90779-69-4 free base) Carbetocin Carbetocin acetate(37025-55-1 free base)

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