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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1817 | GNF-2 | GNF2 | SARS-CoV , Bcr-Abl |
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl. | |||
T6223 | U0126-EtOH | U0126 Ethanol,U0126 | Mitophagy , Influenza Virus , MEK , Autophagy |
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). | |||
T10898 | Samuraciclib hydrochloride | ICEC0942 hydrochloride,CT7001 hydrochloride | Apoptosis , CDK |
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h... | |||
T8685 | SP-146 | Aurora Kinase | |
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM). | |||
T14988 | CMPD1 | MAPK | |
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). | |||
T6152 | PD318088 | MEK | |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | |||
T6546 | IPA-3 | IPA3,IPA 3 | PAK |
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). | |||
T6636 | Refametinib | BAY 86-97661,BAY 869766,RDEA119 | MEK |
Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). | |||
T16560 | Poloxin | PLK | |
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM). | |||
T73331 | GSK3-IN-3 | Mitophagy , GSK-3 | |
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective... | |||
T6083 | AZD8330 | ARRY-424704,ARRY-704 | ERK , MEK |
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. | |||
T2125 | Trametinib | GSK1120212,JTP-74057 | Apoptosis , MEK , Autophagy |
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. | |||
T2443 | CI-1040 | PD 184352 | Apoptosis , MEK |
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). | |||
T1803 | GNF-5 | GNF 5 | SARS-CoV , Bcr-Abl |
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties. | |||
T3067 | Tideglusib | NP-12,NP031112 | GSK-3 |
Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities. | |||
T3419 | Chelerythrine chloride | Apoptosis , BCL , PKC , Autophagy | |
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. | |||
T73269 | CK2α-IN-1 | Casein Kinase | |
CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be used in cancer research. | |||
T25192 | Butyrolactone I | Olomoucin | CDK |
Butyrolactone I (Olomoucin) is an ATP-competitive inhibitor of CDK and cdc2 kinase family. Butyrolactone I shows antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines. | |||
T6189 | Mirdametinib | PD325901,PD0325901 | Apoptosis , MEK , Autophagy |
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis. | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. |