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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9473 | 4SC-203 | FLT | |
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG... | |||
T4191 | Multi-kinase inhibitor 1 | Multi-kinase inhibitor I | Others , Bcr-Abl , PDGFR , c-Kit |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor. | |||
T2056 | VEGFR-2-IN-5 | 2, 4-Pyrimidinediamine with linker,UNC0064-12,2,4-Pyrimidinediamine with linker | VEGFR |
VEGFR-2-IN-5 (UNC0064-12), multikinase inhibitor and has a -NH2 terminal linker for further synthesis. | |||
T4301 | AD80 | Raf , c-RET , Src , S6 Kinase | |
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity. | |||
TQ0317 | R1530 | R-1530,R 1530 | VEGFR , FGFR , FLT , PDGFR |
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities. | |||
T16909 | Sorafenib-d3 | Sorafenib (D3),Bay 43-9006 (D3) | Raf , VEGFR |
Sorafenib-d3 (Bay 43-9006 (D3)) is a deuterium-labeled Sorafenib which is a multikinase inhibitor(IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively). | |||
T0093 | Sorafenib tosylate | Bay 43-9006 | Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy |
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf). | |||
T1792L | Regorafenib monohydrate | Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy | |
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect... | |||
T60108 | PDGFR Tyrosine Kinase Inhibitor III | PDGF Receptor Tyrosine Kinase Inhibitor III | PDGFR |
PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGF... | |||
T8402 | Regorafenib Hydrochloride | BAY73-4506 hydrochloride | Raf , VEGFR , c-RET , PDGFR , Autophagy |
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity | |||
T34656 | SKLB 1028 | Ruserontinib | EGFR , FLT , Bcr-Abl |
SKLB 1028 (Ruserontinib) is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. SKLB 1028 shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants. | |||
T0093L | Sorafenib | Bay 43-9006 | Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy |
Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity... | |||
T82928 | Azido-PEG2-VHL | PROTACs | |
Azido-PEG2-VHL is a multikinase degrader utilized in PROTACs (PROteolysis TArgeting Chimeras) synthesis [1]. | |||
T15542 | Hypothemycin | Others | |
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively). | |||
T12976 | Sorafenib-d4 | Sorafenib (D4),Bay 43-9006 (D4) | Others |
Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC50s of 6 nM, 20 nM, and 22 nM, respectively). | |||
T81740 | Multi-kinase-IN-6 | Trk receptor | |
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX ca... |