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SKLB 1028

Catalog No. T34656 CAS 1350544-93-2

Synonyms: Ruserontinib

SKLB 1028 (Ruserontinib) is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. SKLB 1028 shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants.

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SKLB 1028, CAS 1350544-93-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 146.00

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Purity: 99.85%

Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Ruserontinib
Molecular Weight	443.55
Formula	C24H29N9
CAS No.	1350544-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (112.72 mM)

References and Literature

1. Cao ZX, et al. SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants. Leukemia. 2012 Aug;26(8):1892-5.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Cytoskeletal Signaling Pathway Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SKLB 1028 1350544-93-2 Angiogenesis Cytoskeletal Signaling JAK/STAT signaling Tyrosine Kinase/Adaptors Bcr-Abl EGFR FLT SKLB-1028 SKLB1028 Ruserontinib inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.