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SKLB 1028

Catalog No. T34656 CAS 1350544-93-2

Synonyms: Ruserontinib

SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants.

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SKLB 1028, CAS 1350544-93-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 146.00

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Purity: 99.85%

Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants.

Synonyms	Ruserontinib
Molecular Weight	443.55
Formula	C24H29N9
CAS No.	1350544-93-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (112.72 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cao ZX, et al. SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants. Leukemia. 2012 Aug;26(8):1892-5.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Metabolism Compound Library Bioactive Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Inhibitor Library

Related Products

Related compounds with same targets

EGFR-IN-1 hydrochloride Naluzotan hydrochloride A-935142 BMS-599626 JAK 3 inhibitor IV Naquotinib mesylate Chamigrenal Astragaloside VI

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SKLB 1028 1350544-93-2 Angiogenesis Cytoskeletal Signaling JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR FLT Bcr-Abl Ruserontinib inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.