mechanical — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9685	DS-1971a		Sodium Channel
	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.		Sodium Channel
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T21380	Pravadoline	WIN 48098-6,WIN48098-6,WIN-48098-6	Cannabinoid Receptor
	Pravadoline (WIN48098-6) is a cannabinoid receptor agonist. Pravadoline inhibited the PGs synthesis in mouse brain and displayed antinociceptive activity in rodents subjected to a variety of thermal, chemical, and mechan...		Cannabinoid Receptor
T15050	Danicamtiv	MYK-491,SAR 440181	Myosin
	Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.		Myosin
TP1309	Gastric mucin		Antibacterial , Antibiotic
	Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.		Antibacterial , Antibiotic
T11244	Etimizol	Ethymisol,Ethimizole,Ethymisole	Others
	Etimizol (Ethimizole) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The positive effect of Etimizol on ...		Others
T0156	Rocuronium bromide	ORG 9426,ORG 9426 (Bromide)	AChR
	Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeleta...		AChR
T77340L	AB21 HCl		Sigma receptor
	AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity.		Sigma receptor
T12051	MIV-247		Cysteine Protease
	MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathi...		Cysteine Protease
TP1933	R715 TFA(185052-09-9 free base)	R 715	Bradykinin Receptor
	R715 TFA(185052-09-9 free base) is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Me...		Bradykinin Receptor
TP1220L	Carperitide acetate	Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor
	Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compou...		Endothelin Receptor
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)		Protease-activated Receptor
	FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso...		Protease-activated Receptor
T14198	ALX-1393		GlyT
	ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic cu...		GlyT
T21543	AP 18		TRP/TRPV Channel
	AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 could reverse complete ...		TRP/TRPV Channel
T41005	PA-8		PACAP
	PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vp...		PACAP
T11700	J-2156		Others
	The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type...		Others
T80500	Jingzhaotoxin-X	JZTX-X	Potassium Channel
	Jingzhaotoxin-X (JZTX-X) selectively inhibits Kv4.2 and Kv4.3 potassium channels, resulting in prolonged mechanical hyperalgesia [1].		Potassium Channel
T15167	Draflazine	R-75231	Others
	Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carra...		Others
T23642L	ADR-851 HCl	Adr-851,Adr 851,Adr851
	ADR-851 HCl is an HT3 receptor antagonist. It works against mechanical, acute thermal, and formalin-induced inflammatory pain.
T40173	Spiropyran hexyl methacrylate
	Spiropyran hexyl methacrylate is a compound utilized to create a spiropyran-based polymeric hydrogel, specifically to enable light-activated mechanical actuation.