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MIV-247

Catalog No. T12051 CAS 1352817-76-5

MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.

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MIV-247, CAS 1352817-76-5

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5 mg	In stock	$ 2,750.00
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Purity: 99.31%

ee: 100%

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Description	MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.
Targets&IC50	Cathepsin S (cynomolgus monkey):7.5 nM, Cathepsin S (mouse):4.2 nM, Cathepsin S (human):2.1 nM
In vivo	To assess the potential neurobehavioral side effects of MIV-247, oral administration of MIV-247 (100-200 μmol/kg) resulted in a dose-dependent reduction of mechanical allodynia, with up to approximately 50% reversal observed after single or twice-daily dosing for 5 days. No behavioral deficits were observed with any dose of MIV-247 tested[1].

Molecular Weight	391.39
Formula	C17H24F3N3O4
CAS No.	1352817-76-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):387-96.

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Keywords

MIV-247 1352817-76-5 Proteases/Proteasome Cysteine Protease MIV 247 MIV247 inhibitor inhibit

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