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Rocuronium bromide

Rocuronium bromide
Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
Catalog No. T0156Cas No. 119302-91-9
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Rocuronium bromide

Catalog No. T0156Cas No. 119302-91-9
Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
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Pack SizePriceAvailabilityQuantity
10 mg$45In Stock
50 mg$61In Stock
100 mg$81In Stock
200 mg$105In Stock
500 mg$142In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
In vitro
Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner [1]. It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects [2]. The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes [3].
AliasORG 9426, ORG 9426 (Bromide)
Chemical Properties
Molecular Weight609.68
FormulaC32H53BrN2O4
Cas No.119302-91-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 113 mg/mL (185.3 mM)
H2O: 112 mg/mL (183.7 mM)
Ethanol: 113 mg/mL (185.3 mM)
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.6402 mL8.2010 mL16.4020 mL82.0102 mL
5 mM0.3280 mL1.6402 mL3.2804 mL16.4020 mL
10 mM0.1640 mL0.8201 mL1.6402 mL8.2010 mL
20 mM0.0820 mL0.4101 mL0.8201 mL4.1005 mL
50 mM0.0328 mL0.1640 mL0.3280 mL1.6402 mL
100 mM0.0164 mL0.0820 mL0.1640 mL0.8201 mL

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