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Gastric mucin

Catalog No. TP1309   CAS 84082-64-4

Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.

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Gastric mucin Chemical Structure
Gastric mucin, CAS 84082-64-4
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500 mg In stock $ 42.00
1 g In stock $ 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Gastric mucin is a large glycoprotein which is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma.
In vitro Gastric mucin is a large glycoprotein that is thought to play a major role in the protection of the gastrointestinal tract from acid, proteases, pathogenic microorganisms, and mechanical trauma. Gastric mucin may be integrally involved in the mechanism of gastric mucosal injury caused by Helicobacter pylori leading to gastritis, peptic ulceration, and possibly gastric cancer[1]. Gastric mucins are classified into two types based on their histochemical properties. The first is a surface mucous cell-type mucin, secreted from the surface mucous cells. The second is found in deeper portions of the mucosa and is secreted by gland mucous cells, including mucous neck cells, cardiac gland cells, and pyloric gland cells. The unique O-glycans in gastric mucin appears to function as a natural antibiotic, protecting the host from H. pylori infection[2]. Gastric mucin may provide protection to the surface epithelium gastrointestinal tract by scavenging oxidants produced within the lumen; however, it does so at the expense of its viscoelastic properties. Both native and pronase-treated mucin effectively scavenge hydroxyl radical and that the scavenging properties are not significantly different. The effective concentration of mucin required for a 50% reduction in malondialdehyde production is 10 mg/mL for both native and pronase-treated mucin[3].
Molecular Weight N/A
CAS No. 84082-64-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 0.1 mg/mL (insoluble)

1M NaOH: < 1 mg/mL (insoluble)

TargetMolReferences and Literature

1. Toribara NW, et al. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem. 1993 Mar 15;268(8):5879-85.

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Keywords

Gastric mucin 84082-64-4 Microbiology/Virology Antibacterial Antibiotic inhibit Inhibitor Bacterial inhibitor

 

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