Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate)is a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | In stock | $ 57.00 |
Description | Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate)is a 28-amino acid hormone. Carperitide acetate is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way. |
In vitro | Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II[1]. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[2]. In glomeruli from normal rats, Human 125I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli[3]. |
Synonyms | Carperitide acetate (89213-87-6 Free base), Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate |
Molecular Weight | 3140.5 |
Formula | C129H207N45O41S3 |
CAS No. | 1366000-58-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100mg/ml(31.8mM)
You can also refer to dose conversion for different animals. More
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Carperitide acetate 1366000-58-9 GPCR/G Protein Endothelin Receptor Carperitide Acetate 89213-87-6 Free base 89213-87-6 Carperitide acetate (89213-87-6 Free base) Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate inhibitor inhibit