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Search Results for " leukemia "

20

Compounds

Cat No. Product Name Synonyms Targets
T72098 Eleven-Nineteen-Leukemia Protein IN-3 Epigenetic Reader Domain
Eleven-Nineteen-Leukemia Protein IN-3, an orally active ENL YEATS domain inhibitor, exhibits potent activity with an IC50 of 15.4 nM. It downregulates MYC expression via ENL in cells and enhances ENL protein's thermal st...
T79921 Moloney murine leukemia virus RT DNA/RNA Synthesis
Moloney murine leukemia virus reverse transcriptase (MMLV RT) is a monomeric replicative polymerase intrinsic to the retrovirus life cycle [1].
T72096 Eleven-Nineteen-Leukemia Protein IN-1 Epigenetic Reader Domain
Eleven-Nineteen-Leukemia Protein IN-1 is a potent inhibitor of the ENL YEATS domain, exhibiting an IC50 of 14.5 nM. It binds to the ENL protein, consequently increasing its thermal stability in vitro [1].
T72097 Eleven-Nineteen-Leukemia Protein IN-2 Epigenetic Reader Domain
Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1].
T7664 Pyroxamide Apoptosis , HDAC
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
T3020 Sclareol Apoptosis , Others
Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
T6S1435 Notopterol Apoptosis , Others
1. Notopterol induces apoptosis and inhibits cell cycle-specific.
T37341 N-Acetyltyramine Antibacterial
N-acetyltyramine is a metabolite of the biogenic amine tyramine . It enhances cytotoxicity of doxorubicin in resistant P388 murine leukemia cells with an IC50 value of 0.13 μg/ml compared with an IC50 value of 0.48 μg/ml...
T9339 Stafia-1 STAT
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
TN6512 Tectol Transferase , Parasite
Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti...
T12246 CB-103 Gamma-secretase
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
T12253 Nrf2-IN-1 Others , Nrf2
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
T13186 TL02-59 Apoptosis , Src , Hck
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia cell growt...
T7138 FB23-2 Apoptosis , Others
FB23-2 is a potent and selective mRNA N6-methyladenosine (m6A) demethylase FTO inhibitor(IC50 : 2.6 μM).
T13950 UC-514321 Apoptosis , STAT
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
T9629 BRD4 Inhibitor-24 Epigenetic Reader Domain
BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.
T16363 NVP-2 Apoptosis , CDK
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...
T12943 SNDX-5613 Epigenetic Reader Domain , Histone Methyltransferase
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.
T7200 TAK-960 PLK
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
T9041 AES-350 Apoptosis , HDAC
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, ...
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