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20

Compounds

Cat No. Product Name Synonyms Targets
T9044 SORT-PGRN interaction inhibitor 1 Neurotensin Receptor
SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM).
T3189 B7/CD28 interaction inhibitor 1 CTLA-4 inhibitor Others
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.
T12351 P53 and MDM2 proteins-interaction-inhibitor (racemic) p53-and-mdm2-proteins-interaction-inhibitor-racemic Others
p53 and MDM2 proteins-interaction-inhibitor (racemic) is an inhibitor of the interaction between p53 and MDM2 proteins.
T28219 NusB-NusE interaction inhibitor-1
NusB-NusE interaction inhibitor-1 is a modulator of the NusB-NusE interaction.
T12350 P53 and MDM2 proteins-interaction-inhibitor dihydrochloride Others
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is a interaction inhibitor between p53 and MDM2 proteins.
T79106 SORT-PGRN interaction inhibitor 3 Neurotensin Receptor
SORT-PGRN Interaction Inhibitor 3 (Compound 13), with an IC50 value of 0.17 μM, acts as an inhibitor of the SORT-PGRN interaction, and is utilized in the study of neurodegenerative diseases [1].
T81126 SORT-PGRN interaction inhibitor 2
SORT-PGRN Interaction Inhibitor 2 is a compound that downregulates SORT1 protein expression and enhances extracellular progranulin (PGRN) secretion in various mammalian cell lines, and is utilized in the study of neurolo...
T82244 HA-CD44 interaction inhibitor 2
Antitumor Agent-108 (Compound 5), an inhibitor of the Hyaluronic Acid (HA)-CD44 interaction, effectively disrupts cancer spheroid integrity and exhibits antiproliferative activity against cancer cells [1].
T79756 Beclin1-ATG14L interaction inhibitor 1 Autophagy
Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L. It impedes the formation of complex I in the lipid kinase VPS34, thus inhibiting aut...
T82245 HA-CD44 interaction inhibitor 1
Antitumor agent-109 (compound 6) is a dual-function inhibitor that targets hyaluronic acid and CD44, which are involved in tumor progression and invasion. It demonstrates potent antitumor activity, specifically inhibitin...
T82902 Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].
T3624 A-366 A 366,A366 Epigenetic Reader Domain , Histone Methyltransferase
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...
T5697 BMS-1166 PD-1/PD-L1
BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.
T10860 Col003 HSP
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It can be used for the investigation of fibrosis.
T4647 M2I-1 M2I 1 Others
M2I-1 a small Mad2 inhibitor-1. the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential proteinprotein interaction (PPI) within the SAC. It can disturbs conformational dynamics of Mad2 cri...
T8727 TH1020 TLR , Antibacterial
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T12979 BI-3406 p38 MAPK , MAPK , Ras
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T11857 LIT-001 Oxytocin Receptor
LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
T9986 (E/Z)-ZINC09659342 Rho
(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.
T9461 AZ194 Sodium Channel
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
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TargetMol