hepatocytes — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40588	Acifluorfen		Others
	Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX) and induces tumors in rodent livers. It causes significant photooxidative damage to pigments a...		Others
T0840	Methimazole	Tapazole,Thiamazole	Thyroid hormone receptor(THR)
	Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.		Thyroid hormone receptor(THR)
T9054	RO6889678		HBV
	RO6889678 is HBV inhibitor with a complex ADME profile.		HBV
T2102	FH1	BRD-K4477,NSC 12407	Others
	FH1 (NSC-12407) (BRD-K4477), a small molecule, enhances the functions of hepatocytes and promotes differentiation hepatocytes derived by iPS.		Others
T6506	FPH1	BRD-6125	Others
	FPH1 (BRD-6125) (BRD-6125) can promote the expansion of iPS-derived hepatocytes.		Others
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T4S0779	D-tetrahydropalmatine		Others , Dopamine Receptor
	D-Tetrahydropalmatine is a organic cation transporter 1 (OCT1) inhibitor, it can obviously inhibit the uptake of monocrotaline (MCT) in MDCK-hOCT1 cells and isolate rat primary hepatocytes, and attenuate the viability re...		Others , Dopamine Receptor
T78791	AMPK activator 12		AMPK
	AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.		AMPK
T2172	SQ22536	9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536	AChR
	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isola...		AChR
T4353	SR-18292	SR 18292	Autophagy
	SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.		Autophagy
T19675	SM360320	CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR
	SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...		TLR
T2292	FPH2	BRD-9424	Others
	FPH2 (BRD-9424) (BRD-9424) is a small molecule promoting differentiation of iPS-derived hepatocytes.		Others
T20887	Atorvastatin Sodium	Lipitor	LDL , Aquaporin , HMG-CoA Reductase
	Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to ...		LDL , Aquaporin , HMG-CoA Reductase
T8288	14-Deoxyandrographolide		Apoptosis , Others
	14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.		Apoptosis , Others
T16510	PF-915275		Dehydrogenase
	The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF-915275 is an effective and selective human 11β-hydroxyster...		Dehydrogenase
T5S0281	Tubuloside A		NOS
	Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflammatory effects.Tubuloside A shows stronge...		NOS
T5254	Glycodeoxycholate Sodium	Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt	Others , Endogenous Metabolite
	Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) induces Apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes ex...		Others , Endogenous Metabolite
T5234	Glycoursodeoxycholic acid	Ursodeoxycholylglycine,GUDCA	Others , Endogenous Metabolite
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro...		Others , Endogenous Metabolite
T15367	Gadoxetate Disodium	Gd-EOB-DTPA Disodium,ZK 139834	Others
	Gadoxetate Disodium is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging. It is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary sy...		Others
T3S1068	Oxyresveratrol	trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene	Tyrosinase , Autophagy , HSV
	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid...		Tyrosinase , Autophagy , HSV