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FH1

Catalog No. T2102 CAS 2719-05-3

Synonyms: BRD-K4477, NSC 12407

FH1 (NSC-12407) (BRD-K4477), a small molecule, enhances the functions of hepatocytes and promotes differentiation hepatocytes derived by iPS.

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FH1, CAS 2719-05-3

Pack Size	Availability	Price/USD
10 mg	In stock	$ 42.00
25 mg	In stock	$ 82.00
50 mg	In stock	$ 148.00
100 mg	In stock	$ 263.00
200 mg	In stock	$ 342.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.95%

Purity: 99.23%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FH1 (NSC-12407) (BRD-K4477), a small molecule, enhances the functions of hepatocytes and promotes differentiation hepatocytes derived by iPS.
In vivo	Within hepatocytes, FH1(BRD-K4477) facilitates the differentiation of fully-integrated iHeps into a mature state, enhancing cellular functionality.
Kinase Assay	Affinity determination: Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.

Synonyms	BRD-K4477, NSC 12407
Molecular Weight	282.34
Formula	C17H18N2O2
CAS No.	2719-05-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 52 mg/mL (184.2 mM)

References and Literature

1. Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Keywords

FH1 2719-05-3 Others hHNF4α IPS hALB FH-1 iPSC BRD-K-4477 BRD-K 4477 FH 1 inhibit Inhibitor hNTCP BRD-K4477 hRXR NSC 12407 NSC12407 NSC-12407 inhibitor

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