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SQ22536

Catalog No. T2172 CAS 17318-31-9

Synonyms: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine, SQ 22536

SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated hepatocytes in a non-competitive manner.

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SQ22536, CAS 17318-31-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 289.00
100 mg	In stock	$ 497.00
200 mg	In stock	$ 723.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 98.8%

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Description	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated hepatocytes in a non-competitive manner.
In vitro	SQ22536(250 μMol/L) attenuates the inhibitory effect of adenosine against ADP-induced platelet aggregation from 8±5 to 57±5%, respectively (p<0.001). SQ22536 also attenuates an increase of intraplatelet levels of cAMP by adenosine from 29±2 to 9±1 pmol/108 platelets (p<0.05). It has no effect on the platelet antiaggregant activity of inosine (1 to 4 mmol/L) and ADP-induced platelet aggregation[4].
In vivo	SQ22536 abolishes the renal protective effects of liraglutide in KK/Ta-Akita mice. the amelioration of glomerular histopathological damage by liraglutide is eliminated in KK/Ta-Akita mice treated with liraglutide in combination with SQ22536. Renal cAMP does not increase after treatment with SQ22536. In a word, the beneficial actions of liraglutide for treatment of nephropathy are inhibited by the adenylate cyclase inhibitor SQ22536[5].
Cell Research	HMC-1 cells and hCBMCs are plated in 48-well plates and serum-starved overnight. The next day, cells are preincubated with SQ22536 at the indicated concentrations for 30 min before stimulation with CRH (100 nM for HMC-1 or 1 μM for hCBMC) for 3 min in the presence or absence of SQ22536 in serum-free culture media. Cell lysates are then prepared and assayed for protein kinase A activity using ELISA.(Only for Reference)

Synonyms	9-(tetrahydrofuran-2-yl)-9h-purin-6-amine, SQ 22536
Molecular Weight	205.22
Formula	C9H11N5O
CAS No.	17318-31-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.3 mg/mL (50 mM)

References and Literature

1. Gao Y, et al. Eur J Pharmacol. 2002, 436(3):227-33. 2. Cao J, et al. Mol Pharmacol. 2006, 69(3):998-1006. 3. Xia L, et al. J Endocrinol. 2015, 224(3):225-34. 4. Fuentes E, et al. PLoS One. 2014, 9(11):e112741. 5. Fujita H, et al. Kidney Int. 2014, 85(3):579-89. 6. Ma L, Gong F, Xu J, et al. Uncarboxylated osteocalcin reverses the high glucose‑induced inhibition of the osteogenic differentiation of MC3T3E1 cells via the GPRC6A/cAMP/PKA/AMPK signaling pathway[J]. International Journal of Molecular Medicine. 2021, 47(5): 1-11

Citations

1. Ma L, Gong F, Xu J, et al. Uncarboxylated osteocalcin reverses the high glucose‑induced inhibition of the osteogenic differentiation of MC3T3E1 cells via the GPRC6A/cAMP/PKA/AMPK signaling pathway. International Journal of Molecular Medicine. 2021 May;47(5):91. doi: 10.3892/ijmm.2021.4924. Epub 2021 Mar 31. 2. Zhou J, Shi Y, Yang C, et al.γ-glutamylcysteine alleviates insulin resistance and hepatic steatosis by regulating adenylate cyclase and IGF-1R/IRS1/PI3K/Akt signaling pathways.The Journal of Nutritional Biochemistry.2023: 109404.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Coagulation and Anticoagulation Compound Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max Nucleotide Compound Library

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Keywords

SQ22536 17318-31-9 Neuroscience AChR 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine SQ-22536 Inhibitor inhibit Adenylate Cyclase Adenylyl cyclase SQ 22536 inhibitor

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