hematological — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9575	MRTX9768		Histone Methyltransferase
	MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.		Histone Methyltransferase
T60152	AZ5576		CDK
	AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].		CDK
T13044	Mevociclib	SY-1365	CDK
	Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.		CDK
T0783	Mianserin hydrochloride	Mianserin HCl,Org GB 94,ORG GB-94 HCl	Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
	Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematolog...
T1890	Pracinostat	SB939	Apoptosis , HDAC
	Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff...		Apoptosis , HDAC
T13058	T025		CDK
	T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025...		CDK
TQ0236	Tirabrutinib	ONO-4059,GS-4059,Velexbru	BTK
	Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and ...		BTK
T38951	Isatuximab	SAR-650984,hu38SB19,Isatuximab-irfc	Apoptosis , CD38
	Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has ...		Apoptosis , CD38
T19661	8-Chloroadenosine	NSC 354258,8-Cl-Ado,NSC354258,NSC-354258	AMPK
	8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...		AMPK
T35000	Uproleselan sodium	GMI 1271,GMI1271,GMI-1271
	Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies.
T11603	Ibrutinib-MPEA		Others
	Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies.		Others
T15111	Diacetoxyscirpenol		Others
	Diacetoxyscirpenol, a trichothecene mycotoxin, is a secondary metabolite product of fungi. Diacetoxyscirpenol consumption induces hematological disorders in humans and animals.		Others
T37077	Syk-IN-4
	Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological ...
T21329	Gemcitabine monophosphate disodium salt	Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP
	R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.
T61337	PTG-0861
	PTG-0861 is a highly specific inhibitor of histone deacetylase 6 (HDAC6), demonstrating an impressive IC50 value of 5.92 nm. This compound effectively triggers apoptosis and holds potential for research pertaining to acu...
T63955	MU1656
	MU1656, a potent and selective histone methyltransferase DOT1L inhibitor, demonstrates an IC50 of 2 nM. It is applicable in the research of hematological malignancies [1].
T77183	Ripertamab
	Ripertamab (SCT400), a recombinant human-mouse chimeric anti-CD20 IgG1κ monoclonal antibody (mAb), has applications in the research of hematological malignancies, particularly non-Hodgkin’s lymphoma (NHL) [1].
T76929	Betifisolimab
	Betifisolimab (MSB-2311), a humanized monoclonal antibody targeting the immunosuppressive ligand PD-L1, shows promise for research in advanced solid tumors and hematological malignancies [1].
T79840	Bocodepsin hydrochloride	OKI-179 hydrochloride	HDAC
	Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppression of both solid tumors and hematological malignancies [1].		HDAC
T78516	NUC-7738		Others
	NUC-7738, a 5′-aryloxy phosphoramidate prodrug of 3′-deoxyadenosine (3′-dA), exhibits potent cytotoxic activity against various hematological cancer cell lines and is utilized in cancer research [1].		Others