Powder: -20°C for 3 years | In solvent: -80°C for 2 years
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 338.00 | |
5 mg | In stock | $ 713.00 | |
10 mg | In stock | $ 1,130.00 | |
25 mg | In stock | $ 1,690.00 | |
50 mg | In stock | $ 2,270.00 | |
100 mg | In stock | $ 2,970.00 |
Description | MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. |
Targets&IC50 | cell proliferation:11 nM(HCT116 MTAP-del cells), cell proliferation:861 nM(HCT116 MTAP-WT cells), SDMA:3 nM(HCT116 MTAP-del cells), SDMA:544 nM(HCT116 MTAP-WT cells) |
In vitro | MRTX-9768, a potent inhibitor of SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM). |
In vivo | In xenograft studies, oral administration of MRTX-9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow[1]. |
Molecular Weight | 424.43 |
Formula | C24H17FN6O |
CAS No. | 2629314-68-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 35 mg/ml(82.46 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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MRTX9768 2629314-68-5 Chromatin/Epigenetic Histone Methyltransferase SDMA toxicity glioblastoma orally low Inhibitor hematological MRTX-9768 MTAP CDKN2A MRTX 9768 inhibit anticancer PRMT5-MTA inhibitor