glue — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T18391	N-Boc-4-pentyne-1-amine		Others , PROTAC Linker
	N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound utilized in the synthesis of PROTAC MG-277[1].		Others , PROTAC Linker
T9849	HQ461		CDK , Molecular Glues
	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.		CDK , Molecular Glues
T9758	DCeMM3	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide	Others
	dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati...		Others
T3748	Orcinol	5-Methylresorcinol,3,5-Dihydroxytoluene,5-Methylresorcin,3,5-ToluenediolOrcin,5-Methyl-1,3-benzenediol,Orcin	Others
	orcinol (5-Methylresorcin) is anxiolytic agent without sedative effect.		Others
T75110	Trametiglue
	Trametiglue, a Trametinib derivative, exhibits exceptional potency and selectivity in targeting KSR-MEK and RAF-MEK through distinctive interfacial binding interactions [1].
T10703	Mezigdomide	CC-92480	Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
	Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.		Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
T60608	FPFT-2216		Casein Kinase , PDE , Molecular Glues
	FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune system diseases.		Casein Kinase , PDE , Molecular Glues
T60031	NRX-1933
	NRX-1933 is a molecular glue and enhances the interaction between an oncogenic transcription factor, β-Catenin, and its cognate E3 ligase, SCFβ-TrCP.
T61477	DCeMM2		Molecular Glues
	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.		Molecular Glues
T12617	(R)-CR8 trihydrochloride	CR8, (R)-Isomer trihydrochloride	Apoptosis , CDK
	(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.		Apoptosis , CDK
T67778	DCeMM1		Molecular Glues
	dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells.		Molecular Glues
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T12027	MG-277		Mdm2
	MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.		Mdm2
T79138	Antitumor agent-100 hydrochloride		Molecular Glues
	Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].		Molecular Glues
T75139	TMX1
	TMX1 is a molecular glue degrader that covalently targets BRD4. It selectively recruits DCAF16 to the BRD4 BD2 domain, leading to the degradation of BRD4 [1].
T40342	MC-VC-PABC-amide-PEG1-CH2-CC-885	MC-VC-PABC-amide-PEG1-CH2-CC-885
	MC-VC-PABC-amide-PEG1-CH2-CC-885 is an Antibody-Drug Conjugate (ADC) utilizing a protein-degrading agent (protac molecular glue, etc.).
T81705	Naphthyridine carbamate dimer	NCD	Molecular Glues
	Naphthyridine carbamate dimer (NCD) acts as a molecular glue for DNA, facilitating specific structural alterations within targeted functional DNA sequences to modulate their activity [1].		Molecular Glues
T79139	GBD-9		PROTACs
	GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecu...		PROTACs
T81781	MMH1
	MMH1, a novel molecular glue degrader of BRD4, operates by enlisting the CUL4 and DCAF16 ligases to target the second bromodomain (BRD4 BD2) [1].
T61057	DCeMM4
	dCeMM4 (Compound 5) is a glue degrader that induces cyclin K ubiquitination and degradation through prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex [1].