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Mezigdomide
🥰Excellent
Catalog No. T10703Cas No. 2259648-80-9
Alias CC-92480
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue. Mezigdomide has anti-myeloma activity. [1]
Mezigdomide
🥰Excellent
Purity: 99.60%
Catalog No. T10703Alias CC-92480Cas No. 2259648-80-9
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue. Mezigdomide has anti-myeloma activity. [1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $118 | In Stock | |
| 5 mg | $288 | In Stock | |
| 10 mg | $457 | In Stock | |
| 25 mg | $753 | In Stock | |
| 50 mg | $1,060 | In Stock | |
| 100 mg | $1,430 | In Stock | |
| 500 mg | $2,860 | In Stock |
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Purity:99.60%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that acts as a molecular glue. Mezigdomide has anti-myeloma activity. [1] |
| In vitro | Mezigdomide (CC-92480)-induced loss of Aiolos and Ikaros in PBMC cultures resulted in T cell activation and increased IL-2 and IFN-γ production; Mezigdomide (CC-92480) induced apoptosis as a single agent and exhibited significant synergy with NSC 34521; Mezigdomide (CC-92480) was effective against CC-4047, CC-5013, and CC-220 resistant cell lines. [2] |
| In vivo | Mezigdomide (1 mg/kg) reduced tumor volume by 75% when administered orally to tumor-bearing mice for 21 days[2]. |
| Alias | CC-92480 |
| Molecular Weight | 567.61 |
| Formula | C32H30FN5O4 |
| Cas No. | 2259648-80-9 |
| Smiles | O(CC1=CC=C(CN2CCN(CC2)C3=C(F)C=C(C#N)C=C3)C=C1)C4=C5C(C(=O)N(C5)[C@@H]6C(=O)NC(=O)CC6)=CC=C4 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (8.81 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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