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Mezigdomide

Catalog No. T10703   CAS 2259648-80-9
Synonyms: CC-92480

Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.

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Mezigdomide Chemical Structure
Mezigdomide, CAS 2259648-80-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 118.00
5 mg In stock $ 288.00
10 mg In stock $ 457.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
500 mg In stock $ 2,860.00
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Purity: 98.8%
Purity: 97.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
In vitro Mezigdomide-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. Mezigdomide exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. Mezigdomide is effective in CC-4047, CC-5013, and CC-220-resistant cell lines[1].
In vivo Mezigdomide (1 mg/kg) showed 75% reduction in tumor volume when tumor-bearing mice were dosed orally for 21 days. Both the 3 and 10 mg/kg doses gave near maximal response in this model[2].
Synonyms CC-92480
Molecular Weight 567.61
Formula C32H30FN5O4
CAS No. 2259648-80-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (8.81 mM), Sonification and heating to 60℃ are recommended.

TargetMolReferences and Literature

1. Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31. 2. Hansen JD, Correa M, et al. Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. J Med Chem. 2020 Jul 9;63(13):6648-6676. 3. You W, Pang J. Pharmacokinetics, bioavailability and metabolism of CC-92480 in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 2021 Sep;35(9):e5139.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Ubiquitination Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Clinical Compound Library

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Keywords

Mezigdomide 2259648-80-9 Apoptosis PROTAC Ubiquitination Molecular Glues E1/E2/E3 Enzyme Ubiquitin ligase Ubiquitin activating enzyme CC 92480 CC92480 inhibit E1 activating enzyme CC-92480 E2 conjugating enzyme Inhibitor Ubiquitin conjugating enzyme E3 ligating enzyme inhibitor

 

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