Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 118.00 | |
5 mg | In stock | $ 288.00 | |
10 mg | In stock | $ 457.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,060.00 | |
100 mg | In stock | $ 1,430.00 | |
500 mg | In stock | $ 2,860.00 |
Description | Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity. |
In vitro | Mezigdomide-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. Mezigdomide exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. Mezigdomide is effective in CC-4047, CC-5013, and CC-220-resistant cell lines[1]. |
In vivo | Mezigdomide (1 mg/kg) showed 75% reduction in tumor volume when tumor-bearing mice were dosed orally for 21 days. Both the 3 and 10 mg/kg doses gave near maximal response in this model[2]. |
Synonyms | CC-92480 |
Molecular Weight | 567.61 |
Formula | C32H30FN5O4 |
CAS No. | 2259648-80-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (8.81 mM), Sonification and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Mezigdomide 2259648-80-9 Apoptosis PROTAC Ubiquitination Molecular Glues E1/E2/E3 Enzyme Ubiquitin ligase Ubiquitin activating enzyme CC 92480 CC92480 inhibit E1 activating enzyme CC-92480 E2 conjugating enzyme Inhibitor Ubiquitin conjugating enzyme E3 ligating enzyme inhibitor