Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
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Description | MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner. |
In vitro | MG277 has a significantly decreased potency in reducing the level of MDM2 protein in cells and fails to activate wild-type p53. MG-277 is highly potent and effective in inhibition of cell growth in cancer cell lines with wild-type p53, mutated p53, or deleted p53, indicating a p53-independent mechanism. MG-277 induces rapid GSPT1 degradation in cancer cells in a p53- and MDM2-independent manner but in a manner dependent upon cereblon, CUL4 E3 ubiquitin ligase, and proteasomes[1]. |
Molecular Weight | 774.71 |
Formula | C41H42Cl2FN5O5 |
CAS No. | T12027 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MG-277 T12027 Apoptosis Mdm2 MG277 MG 277 inhibitor inhibit