20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8266 | (R)-Citronellol | D-Citronellol,(R)-(+)-β-Citronellol | Others , Endogenous Metabolite |
(R)-Citronellol ((R)-(+)-β-Citronellol) is found in herbs and spices, as well as bilberry. (R)-Citronellol is a constituent of black cumin (Nigella sativa) seeds. (R)-Citronellol is a common constituent of plant oils, es... | |||
T2238 | Cariporide | HOE-642 | Sodium Channel |
Cariporide (HOE-642) (HOE-642), an effective NHE1 inhibitor, has inhibitory effects on the degranulation of human platelets, the formation of platelet-leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (... | |||
T29221 | (R)-ZINC-3573 | ZINC 3573 | Others |
(R)-ZINC-3573 is a potent and highly selective MRGPRX2 probe. (R)-ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line, inducing degranulation and calcium release. | |||
TN7075 | Linocinnamarin | 3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester | Phospholipase , Syk |
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivati... | |||
TN1136 | Procyanidin A1 | Proanthocyanidin A1 | LDL , Calcium Channel , PKC |
Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. | |||
TN1516 | Cnidicin | NOS , NO Synthase | |
Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr... | |||
TP1909L1 | CALP2 acetate(261969-04-4 free base) | CaMK , PDE | |
CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM. CALP2 acetate potently inhibits of adhesion and degranulation. CALP2 acetate is als... | |||
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... | |||
TP1956L | PKC ζ pseudosubstrate acetate | PKC ζ pseudosubstrate acetate (799764-07-1 free base) | PKC |
PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by... | |||
T15666 | KP136 | AL136 | Others |
KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation). | |||
T63394 | MrgprX2 antagonist-6 | ||
MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation. | |||
T72016 | ST101036 | ||
MC activators have recently been described as safe and effective vaccine adjuvants. ST101036 exhibited high degranulation potency in both human and mouse MCs. | |||
T0260L | Meclofenamate sodium hydrate | INF 4668,CI583,CI-583,INF-4668,CI 583,INF4668 | |
Meclofenamate sodium is a potent non-steroidal anti-inflammatory agent, which can specifically inhibit chemokine-induced human polymorphonuclear leukocyte function: chemotaxis, degranulation, and superoxide anion free ra... | |||
T38087 | 20-hydroxy Leukotriene B4 | 20-hydroxy Leukotriene B4 | |
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing deg... | |||
T41103 | Compound 48/80 | Poly-p-methoxyphenethylmethylamine | |
Compound 48/80, also known as Poly-p-methoxyphenethylmethylamine, is a commonly utilized mast cell activator in animal and tissue models. This compound exerts its effect by stimulating trimeric G-proteins at the mast cel... | |||
T38127 | PNPS-DHA | ||
pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cut... | |||
T63766 | MrgprX2 antagonist-7 | ||
MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation. | |||
T37618 | Leukotriene B4 dimethyl amide | Leukotriene B4 dimethyl amide | |
LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on gui... | |||
TP1946 | QWF | ||
Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced... |