Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation). |
In vitro | KP136 (0.01 μg/mL) inhibits this histamine release and degranulation in a dose-dependent manner. This confirms it is an inhibitor of mast cell activation[1]. |
In vivo | KP136, administered intravenously at a dose of 1 mg/kg, significantly inhibits 5-h homologous passive cutaneous anaphylaxis (PCA), demonstrating efficacy comparable to C4C. A dose of 0.2 mg/kg of C4C yields an effect equivalent to 1 mg/kg of KP136 or 5 mg/kg of DSCG. However, C4C shows reduced effectiveness when administered orally, achieving a maximum inhibition rate of approximately 35% even at a high dose of 100 mg/kg. In contrast, KP136 exerts a pronounced inhibitory effect of about 66% at an oral dose of 2 mg/kg [1]. |
Synonyms | AL136 |
Molecular Weight | 314.34 |
Formula | C16H18N4O3 |
CAS No. | 76239-32-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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KP136 76239-32-2 Others AL 136 KP-136 AL-136 KP 136 AL136 inhibitor inhibit