damaging — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14349	Auristatin F		Microtubule Associated
	Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.		Microtubule Associated
T6116L	Bleomycin hydrochloride		DNA/RNA Synthesis
	Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.		DNA/RNA Synthesis
T5780	HYPOCRELLIN B		Apoptosis , Parasite , Antifungal
	HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by incre...		Apoptosis , Parasite , Antifungal
T0146	Tioconazole	UK-20349,Vagistat	Antibiotic , Antifection , Antifungal
	Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and pr...		Antibiotic , Antifection , Antifungal
TMS2180	Zeaxanthin	Anchovyxanthin,All-Trans-Zeaxanthin	Antioxidant , Endogenous Metabolite
	1. Lutein and Zeaxanthin (All-Trans-Zeaxanthin) in neural tissue may have biological effects that include antioxidation, anti-inflammation, and structural actions. 2. Lutein and Zeaxanthin may be protective against eye d...		Antioxidant , Endogenous Metabolite
T2213	Terconazole	Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,R42470	Antifection , Antifungal
	Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damag...		Antifection , Antifungal
T77520	AOH1996		Apoptosis , DNA/RNA Synthesis
	AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...		Apoptosis , DNA/RNA Synthesis
T41245	Trimethylamine N-oxide		Reactive Oxygen Species , NOD-like Receptor (NLR) , TGF-beta/Smad
	Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in tissues of marine animals and prevents the protein-damaging e...
T41163	ZNL 02-096	Pomalidomide-C3-adavosertib	Apoptosis , Wee1
	ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ...		Apoptosis , Wee1
T29263	(S,S)-D211	(S,S)-D-211,IQB dimer (S,S)-D211
	(S,S)-D211 is a DNA damaging payload.
TN3623	Cepharadione A		Others
	Cepharadione A is a naturally occurring DNA damaging agent.		Others
T73719	Azoxymethane	AOM	DNA
	Azoxymethane (AOM) is a DNA damaging agent that induces cancer and can be used in mouse models of colorectal cancer.		DNA
T20788	Empenthrin	MA-108,S2852,S 2852,MA108,S-2852,MA 108
	Empenthrin, a synthetic pyrethroid used in insecticides, is active against broad spectrum of flying insects including moths and other pests damaging textile.
T24176	(-)-Irofulven	MGI-114,NSC-683863,MGI 114,HMAF,MGI114,Irofulven
	Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.
T78166	MEL24		Others
	MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1].		Others
T37876	Fengycin
	Fengycin, a cyclic lipopeptide, functions as an agricultural fungicide by exhibiting an anti-fungal infection effect through damaging the target's cell membrane[1].
T38414	NSC 80467
	NSC 80467, a selective DNA damaging agent, functions by inhibiting survivin. Specifically, it preferentially targets DNA synthesis, leading to the induction of two distinct markers of DNA damage, namely γH2AX and pKAP1.
TN5072	Strictosidine		Others
	Strictosidine has DNA damaging activity in yeast RS 188N mutant, assessed as drug level required to produce 12 mm zone of inhibition.		Others
T16283	Neocarzinostatin		5-HT Receptor
	Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti...		5-HT Receptor
T36733	HLI373 dihydrochloride
	HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 di...