antimetastatic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11363	Ganoderic acid F		Others
	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si...		Others
T6496	Vactosertib	TEW-7197,EW-7197	ALK , TGF-beta/Smad
	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...		ALK , TGF-beta/Smad
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T24833	ZINC69391	ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)	Apoptosis , Rho
	ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP le...		Apoptosis , Rho
T3691	(Rac)-SAR131675	SAR131675	VEGFR
	(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is h...		VEGFR
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
T2S1865	Octyl gallate	Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8	Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV
	1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ...
T27887	LY 189332	LY189332,LY-189332
	LY 189332 is an drug with antimetastatic activity.
T15262	Vactosertib Hydrochloride	TEW-7197 Hydrochloride,EW-7197 Hydrochloride	ALK
	Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50...		ALK
T63791	HDAC-IN-36
	HDAC-IN-36 is an orally active HDAC (histone deacetylase) inhibitor with an IC50 value of 11.68 nM for HDAC6. HDAC-IN-36 induces apoptosis, autophagy and inhibits migration. HDAC-IN-36 exhibits antitumor and antimetastat...
TMA0424	Martynoside		ROS
	Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the me...		ROS
T78742	Anticancer agent 132		Apoptosis
	Compound Rh1 (Anticancer agent 132) acts as an inducer of apoptosis and autophagy, exhibiting both antitumor and antimetastatic activities. It also arrests the cell cycle and inhibits cell proliferation [1].		Apoptosis
T72569	Cathepsin L/S-IN-1
	Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv...
T78743	Anticancer agent 133		Apoptosis
	Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy. Additionally, it suppresses cell metastasis through the inhibition of EGFR expression,...		Apoptosis
T76162	Stem bromelain
	Stem bromelain (EC 3.4.22.32), a cysteine proteinase from pineapple (Ananas comosus) stem, is a significant type of bromelain known for its fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory properties. I...
T79560	22-(4′-py)-JA	22-(4′-Pyridinecarbonyl) jorunnamycin A	Akt
	22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumo...		Akt