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Martynoside

Name: Martynoside
Brand: TargetMol
SKU: TMA0424
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMA0424Cas No. 67884-12-2

Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.

Martynoside

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Purity: 99.83%

Catalog No. TMA0424Cas No. 67884-12-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	-	In Stock
5 mg	$372	-	In Stock
10 mg	$596	-	In Stock
25 mg	$933	-	In Stock
50 mg	$1,250	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Martynoside is an active glycoside extracted from Rehmannia, with anti-estrogen, anticancer, cytotoxic, hematopoietic, antioxidant, and anti-metastatic properties. It increases IGFBP3 levels through the ER pathway.
In vitro	Martynoside attenuated 5-FU-induced cytotoxicity of bone marrow nucleated cells, increased the stability of RPL27A protein, and reduced RPL27A ubiquitination at lys92 (K92) and lys94 (K94) sites. [1] Martynoside(50 μg/ml) protects isolated bone marrow cells from 5-fluorouracil (5-FU) -induced cell death and inflammation by down-regulating the TNF signaling pathway. [2]
In vivo	Martynoside 10 mg/kg daily and receiving exercise for 5 weeks was found to have the potential to antagonize exercise anemia, and the mechanism of this effect may be related to preventing free radical damage to red blood cells. [3]

Chemical Properties

Molecular Weight	652.64
Formula	C₃₁H₄₀O₁₅
Cas No.	67884-12-2
Smiles	O([C@H]1[C@H](OC(/C=C/C2=CC(OC)=C(O)C=C2)=O)[C@@H](CO)O[C@@H](OCCC3=CC(O)=C(OC)C=C3)[C@@H]1O)[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4
Relative Density.	1.48g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (24.52 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5322 mL	7.6612 mL	15.3224 mL	76.6119 mL
5 mM	0.3064 mL	1.5322 mL	3.0645 mL	15.3224 mL
10 mM	0.1532 mL	0.7661 mL	1.5322 mL	7.6612 mL
20 mM	0.0766 mL	0.3831 mL	0.7661 mL	3.8306 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc