sirt3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T4108	3-TYP	3-(1H-1,2,3-triazol-4-yl) pyridine	Sirtuin
	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.		Sirtuin
T8480	Tenovin-6 Hydrochloride		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
	Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .		Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
T2412	SRT1720 hydrochloride	SRT1720 HCl,SRT 1720 Hydrochloride	Sirtuin
	SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).		Sirtuin
T5124	SRT 1720 dihydrochloride[925434-55-5(free base)]		Sirtuin
	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).		Sirtuin
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T3447	Thiomyristoyl		Sirtuin
	Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.		Sirtuin
T5096	SRT 1720		Sirtuin , Autophagy
	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.		Sirtuin , Autophagy
T1818	Tenovin-6	Tenovin 6	Dehydrogenase , Sirtuin , Autophagy
	Tenovin-6 is a p53 transcriptional activity agonist.		Dehydrogenase , Sirtuin , Autophagy
T13795	Nicotinamide riboside		Sirtuin
	Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.		Sirtuin
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T6371	AGK2		Apoptosis , Sirtuin
	AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.		Apoptosis , Sirtuin
T3S0175	Gardenia yellow	alpha-Crocin,Crocin I,Crocine	Sirtuin
	Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.		Sirtuin
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T6220	Nicotinamide riboside chloride		Sirtuin , Endogenous Metabolite
	Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.		Sirtuin , Endogenous Metabolite
T12919	SIRT-IN-2		Sirtuin
	SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).		Sirtuin
T12918	SIRT-IN-1		Sirtuin
	SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).		Sirtuin
T35822	CAY10722
	CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functio...
T60257	SIRT-IN-3
	SIRT-IN-3, a potent inhibitor of SIRT1 with an IC50 value of 17 μM, exhibits approximate 4-fold and 14-fold greater selectivity for SIRT1 over SIRT2 and SIRT3, with respective IC50 values of 74 μM for SIRT2 and 235 μM fo...
T35821	CAY10721
	CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph no...