Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively). |
Targets&IC50 | SIRT1:4 nM, SIRT3:7 nM, SIRT2:1 nM |
In vitro | SIRT-IN-2 is one of the most potent truncated pan SIRT1/ 2/3 inhibitor(IC50 values are 4, 4, 7 μM, respectively). SIRT-IN-2 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. |
Molecular Weight | 383.49 |
Formula | C15H21N5O3S2 |
CAS No. | 1431411-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (151.24 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SIRT-IN-2 1431411-66-3 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor SIRT IN 2 inhibit SIRTIN2 inhibitor