Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
500 mg | In stock | $ 2,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 266.00 |
Description | SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively). |
Targets&IC50 | SIRT1:15 nM, SIRT3:33 nM, SIRT2:10 nM |
In vitro | SIRT-IN-1 is one of the most potent inhibitor of truncated pan SIRT1/ 2/3(IC50 values are 0.015, 0.010, 0.033 μM, respectively). SIRT-IN-1 binds identically in the catalytic active site (RMS=0.29 ), occupying the nicotinamide C-pocket and acetyl lysine substrate channel. |
Molecular Weight | 389.52 |
Formula | C19H27N5O2S |
CAS No. | 1431411-60-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 19.23 mg/mL (49.37 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SIRT-IN-1 1431411-60-7 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor SIRT IN 1 SIRTIN1 inhibit inhibitor