13
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1507 | Streptozocin | STZ,Streptozotocin,NSC-85998,U 9889 | DNA Alkylator/Crosslinker , DNA Alkylation , DNA/RNA Synthesis , Antibacterial , Antibiotic , Autophagy |
Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used in the construction of animal models of type 1 diabetes. Th... | |||
T0674 | Lansoprazole | A-65006,AG-1749 | Proton pump , Phospholipase , Antibacterial |
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo... | |||
T60739L | Y13g dihydrochloride | Y13g 2HCl(T60739 Free base) | IL Receptor , AChE |
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are related). Y13g dihydrochloride reverses STZ-induced memory defi... | |||
T5444 | CLP290 | CLP-290 | Potassium Channel |
CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications. | |||
TP2338 | Cenupatide | UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2) | |
Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupa... | |||
T61040 | Vin-F03 | ||
Vin-F03 can be used in the research of type 2 diabetes mellitus that is an effective protective agent of pancreatic β-cells (EC50 = 0.27 μM). Vin-F03 potently promotes the survival of β-cell and protects β-cells from apo... | |||
T60739 | Y13g | ||
Y13g is the potent inhibitor of Interleukin-6 (IL-6) and acetylcholinesterase(AChE) which are two important targets implicated in Alzheimer's Disease(AD) progression. Y13g reverses the memory deficit induced by STZ as we... | |||
T60743 | Vin-C01 | ||
Vin-C01 can be used for the research of type 2 diabetes mellitus that is a potent protective agent of pancreatic β-cells (EC 50 = 0.22 μM). Vin-C01 effectively protects β-cells from apoptosis induced by STZ and promotes ... | |||
TMA0127 | Ficusin A | transporter , PPAR | |
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPAR... | |||
T78066 | BBT | Calcium Channel | |
BBT enhances glucose-stimulated insulin secretion (GSIS) in compromised conditions, demonstrates anti-hyperglycemia effects, and shields β-cells from cytokine- or streptozotocin (STZ)-triggered apoptosis in type 2 diabet... | |||
TN4997 | Serpentine | IGF-1R | |
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose up... | |||
T83688 | R 715 TFA | [Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH | |
R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances... | |||
T71981 | Gliclazide-d4 | ||
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ... |