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Lansoprazole

Catalog No. T0674 CAS 103577-45-3

Synonyms: A-65006, AG-1749

Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)

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Lansoprazole, CAS 103577-45-3

Pack Size	Availability	Price/USD
500 mg	In stock	$ 45.00
1 g	In stock	$ 62.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.84%

Purity: 99.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
In vitro	Lansoprazole significantly attenuates intestinal damage induced by ischemia-reperfusion or indomethacin. Exogenous administration of Lansoprazole can prevent injury to the small intestine caused by ischemia-reperfusion or indomethacin. Lansoprazole inhibits acute inflammatory responses and mucosal injury in rats subjected to ischemia-reperfusion or indomethacin-induced damage.
In vivo	Lansoprazole is a potent antisecretory agent that inhibits gastric acid secretion by blocking the stomach's hydrogen/potassium adenosine triphosphatase (H+, K+-ATPase). It suppresses the upregulation of adhesion molecules in blood vessels, neutrophil activation, and the production of pro-inflammatory cytokines from activated endothelial cells. Furthermore, Lansoprazole induces the expression of various genes in gastric epithelial cells, including Phase II detoxifying enzymes (NADPH-quinone oxidoreductase, glutathione S-transferase) and antioxidative stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase). In rat gastric epithelial cells, Lansoprazole upregulates HO-1 expression and exerts anti-inflammatory effects.

Synonyms	A-65006, AG-1749
Molecular Weight	369.36
Formula	C16H14F3N3O2S
CAS No.	103577-45-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1eq. HCl: 18.5 mg/mL (50 mM)

DMSO: 36.9 mg/mL (100 mM)

References and Literature

1. Garnett WR, et al. Ann Pharmacother, 1996, 30(12), 1425-1436. 2. Takagi T, et al. J Clin Biochem Nutr, 2009, 45(1), 9-13. 3. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches[J]. RSC Advances. 2018 Jan 8(10): 5286-5297.

Citations

1. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches. RSC Advances. 2018 Jan 8(10): 5286-5297.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library FDA-Approved Drug Library Metabolism Compound Library Ferroptosis Compound Library Anti-Obesity Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Lansoprazole Sulfide D4 Lansoprazole-d4 Bamaquimast Esomeprazole Abscisic Acid EN6 Abeprazan hydrochloride Esomeprazole Sodium

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Keywords

Lansoprazole 103577-45-3 Membrane transporter/Ion channel Metabolism Microbiology/Virology Antibacterial Phospholipase Proton pump acid AG1749 N-SMase A65006 ELT TSTQ Bacterial inhibit exosome Proton Pump gastric HFD STZ A-65006 A 65006 AG-1749 AG 1749 Inhibitor inhibitor

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