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CLP290

Catalog No. T5444 CAS 1181083-81-7

Synonyms: CLP-290

CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.

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CLP290, CAS 1181083-81-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 68.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 215.00
50 mg	In stock	$ 344.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 100%

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Description	CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.
In vivo	In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons.?Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
Animal Research	Morphine sulfate (50 mg/ml) was diluted in saline sterile solution immediately before injection.?Morphine or saline were subcutaneously injected twice a day (10 mg/kg;?9 a.m. 6 p.m.) in na?ve adult rats.?The KCC2 enhancer CLP257 and its carbamate pro-drug CLP290 were freshly diluted in 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) prior injection.?CLP257 or vehicle were delivered intraperitoneally after 7 8 days of morphine or saline, as described (100 mg/kg).?CLP290 or vehicle were delivered orally by gavage twice a day for the whole duration of the morphine/saline treatment (100 mg/kg).

Synonyms	CLP-290
Molecular Weight	404.46
Formula	C19H21FN4O3S
CAS No.	1181083-81-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (29.67 mM)

References and Literature

1. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870.

Related compound libraries

This product is contained In the following compound libraries：

Orally Active Compound Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Potassium Channel Blocker Library Covalent Inhibitor Library Ion Channel Inhibitor Library

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Keywords

CLP290 1181083-81-7 Membrane transporter/Ion channel Potassium Channel inhibit Inhibitor CLP-290 CLP 290 KcsA inhibitor

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