ppar-γ — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22708	Darglitazone	CP-86325	PPAR
	Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions. Darglitazone is effective in controlling blood glucose and lipid metabolism.		PPAR
T1461	Candesartan	CV 11974	RAAS
	Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.		RAAS
T1633	β-Carotene	Carotaben,Beta-Carotene,Provitamin A	Apoptosis , ROS , Endogenous Metabolite
	β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...		Apoptosis , ROS , Endogenous Metabolite
TQ0156	GW1929		PPAR
	GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).		PPAR
T15575	Indeglitazar	PPM 204	PPAR
	Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).		PPAR
T27303	Farglitazar	GI-262570,GI-2570,GW 262570X,GI 262570,GI262570	PPAR
	Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer that inhibits stellate cell activation by activating receptor γ via oxidative enzymes proliferators and is used in the study of diabetes.		PPAR
T21587	Muraglitazar	Pargluva,BMS-298585	PPAR
	Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα and PPARγ with EC50 of 320 nM and 110 nM r...		PPAR
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
TN1693	Glabrone		Influenza Virus , PPAR
	Glabrone shows antiviral activity against influenza virus.		Influenza Virus , PPAR
T8780	AMG131	INT-131,AMG-131,CHS 131	PPAR
	AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin depende...		PPAR
T2946	Tanshinone IIA sulfonate sodium	Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium	CaMK , P450 , Calcium Channel
	Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor...		CaMK , P450 , Calcium Channel
T16739	RG-12525	NID 525	Leukotriene Receptor , PPAR
	RG-12525（NID 525） is an orally available, selective and competitive leukotriene D (LTD) antagonist that inhibits LTC4, LTD4 and LTE4-induced contraction of guinea pig thin-walled bands, with IC50 values of 2.6 nM, 2.5 nM...		Leukotriene Receptor , PPAR
T2932	Ginsenoside Rh1	Sanchinoside B2,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor , TNF , Endogenous Metabolite , PPAR , Interleukin
	Ginsenoside Rh1 (Sanchinoside B2) , one of the main constituents of Panax ginseng, exhibits anti-inflammatory effect.
T7621	6-Thioinosine	6-Mercaptopurine riboside,6TI	Nucleoside Antimetabolite/Analog
	6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.		Nucleoside Antimetabolite/Analog
T16022	Arhalofenate	JNJ 39659100,MBX 102	PPAR
	Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.		PPAR
TN1018	Angeloylgomisin H		PPAR
	Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.		PPAR
TN2601	12-O-Methylcarnosic acid		Reductase
	12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity...		Reductase
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside	tetrahydroxyl diphenylethylene-2-o-gluco,EH-201	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc...		Others
T17044	Tesaglitazar		PPAR
	Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...		PPAR
T3867	Alpinetin	(-)-alpinetin	BCL , PPAR
	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he...		BCL , PPAR