Search Result

Search Results for " pdgfr-β "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
T6036	Brivanib	BMS-540215	EGFR , VEGFR , FGFR , Autophagy
	Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold against PDGFR-β. Phase 3.		EGFR , VEGFR , FGFR , Autophagy
T15616	JNJ-10198409	JNJ-10198409	PDGFR
	JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, ant...		PDGFR
T3476	JI-101	CGI-1842,JI 101	VEGFR , PDGFR , Ephrin Receptor
	JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4).		VEGFR , PDGFR , Ephrin Receptor
T1792L	Regorafenib monohydrate		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
	Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respect...		Raf , VEGFR , c-RET , PDGFR , c-Kit , Autophagy
T4349	Sitravatinib	MG516,MGCD516	Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T6711	Tyrphostin AG1296	Tyrphostin AG 1296,AG 1296	Apoptosis , FGFR , FLT , PDGFR , c-Kit
	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.		Apoptosis , FGFR , FLT , PDGFR , c-Kit
T6091	CP-673451		VEGFR , PDGFR , c-Kit
	CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than other angiogenic receptors.		VEGFR , PDGFR , c-Kit
T3463	NVP-ACC789	ACC-789,ZK202650	VEGFR , PDGFR
	ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.		VEGFR , PDGFR
T3211	Midostaurin	N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251	Others , PKC
	PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel...		Others , PKC
T71897	Vatalanib succinate
	Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor.
T23660	AG1433	Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433
	AG1433 is a tyrosine kinases inhibitor that acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived g...
T79530	SA-PA		PROTACs
	SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-...		PROTACs
T28874	SU11652	SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF...
T29542	AC708	AC 708,AC-708
	AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells culture...
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase i...

Compounds

PD-161570

T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Brivanib

T6036

Synonym: BMS-540215

Target: EGFR, VEGFR, FGFR, Autophagy

JNJ-10198409

T15616

Synonym: JNJ-10198409

Target: PDGFR

JI-101

T3476

Synonym: CGI-1842,JI 101

Target: VEGFR, PDGFR, Ephrin Receptor

Regorafenib monohydrate

T1792L

Synonym:

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Sitravatinib

T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Tyrphostin AG1296

T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

CP-673451

T6091

Synonym:

Target: VEGFR, PDGFR, c-Kit

NVP-ACC789

T3463

Synonym: ACC-789,ZK202650

Target: VEGFR, PDGFR

Midostaurin

T3211

Synonym: N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251

Synonym: Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433

Synonym: SU-11652,SU 11652

Target:

AC708

T29542

Synonym: AC 708,AC-708

Cat No.	Product Name	Synonyms	Targets
T2734	Sennoside B		PDGFR
	Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.		PDGFR

Natural Products

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00481	PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity ...
TMPK-00422	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa and the accession number is P09619.
TMPK-01050	PDGF R beta/CD140b Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	PDGF R beta/CD140b Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.25 kDa and the accession number is Q6QNF3.
TMPK-00421	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa and the accession number is P09619.
TMPY-05358	PDGFRB Protein, Human, Recombinant	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 56.2 kDa and the accession number is P09619-1.
TMPY-04937	PDGFRB Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1.
TMPY-05497	PDGFRB Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.8 kDa and the accession number is P09619-1.
TMPY-01207	PDGFRB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	PDGFRB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P09619-1.
TMPK-01178	PDGFD Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Platelet‑derived growth factor D (PDGF‑D) is a new member of the PDGF family that binds the PDGFR‑β homodimer. PDGF‑D promotes the angiogenic capacity of EPCs, including proliferation, migration, adhesion and tube format...